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2-Amino-3-benzyloxypyridine

Name: 2-Amino-3-benzyloxypyridine
Brand: ALDRICH

99%

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Empirical Formula (Hill Notation):

C₁₂H₁₂N₂O

CAS Number:

24016-03-3

Molecular Weight:

200.24

EC Number:

245-983-9

MDL number:

MFCD00006316

PubChem Substance ID:

24848659

NACRES:

NA.22

Assay

99%

form

solid

mp

92-94 °C (lit.)

SMILES string

Nc1ncccc1OCc2ccccc2

InChI

1S/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)

InChI key

NMCBWICNRJLKKM-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Related Categories

Heterocyclic Building Blocks

General description

2-Amino-3-benzyloxypyridine on condensation with diethyl ethoxymethylene malonate affords 9-benzyloxy-3-ethoxycarbonylpyrido[1,2-a]pyrimidin-4-one.

Application

2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.

Biochem/physiol Actions

2-Amino-3-benzyloxypyridine is an inhibitor of mitogen-activated protein kinase p38α activity.

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis of new heterocyclic phenols: 9-Hydroxypyrido [1, 2-a] pyrimidin-4-one and Derivatives.

Dennin F, et al.

Journal of Heterocyclic Chemistry, 28(5), 1287-1291 (1991)

Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.

J Chang-Fong et al.

Chemical & pharmaceutical bulletin, 48(5), 729-733 (2000-05-24)

In order to obtain possible veinotonic drugs acting through alpha2 receptor activation, we prepared clonidine analogues in which the 2-imino-imidazolidine was attached to various aliphatic or aromatic heterocycles. Among them, the two benzopyranic derivatives 16 and 22 exhibited interesting affinities

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Jung-Eun Park et al.

European journal of medicinal chemistry, 141, 322-334 (2017-10-17)

Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Ahmed Elkamhawy et al.

European journal of medicinal chemistry, 128, 56-69 (2017-02-06)

Herein, we report a new series of aliphatic substituted pyridyl-urea small molecules synthesized as potential modulators for amyloid beta (Aβ) induced mitochondrial dysfunction. Their blocking activities against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which

Rapid identification of ligand-binding sites by using an assignment-free NMR approach.

Yuya Kodama et al.

Journal of medicinal chemistry, 56(22), 9342-9350 (2013-11-01)

In this study, we developed an assignment-free approach for rapid identification of ligand-binding sites in target proteins by using NMR. With a sophisticated cell-free stable isotope-labeling procedure that introduces (15)N- or (13)C-labels to specific atoms of target proteins, this approach

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