156124
Oxonic acid potassium salt
97%
Synonym(s):
4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt, Allantoxanic acid
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C4H2KN3O4
CAS Number:
Molecular Weight:
195.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
218-627-5
MDL number:
Assay:
97%
Quality Level
assay
97%
mp
300 °C (lit.)
SMILES string
[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1
InChI
1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
InChI key
IAPCTXZQXAVYNG-UHFFFAOYSA-M
Application
Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
T Shirasaka et al.
Cancer research, 53(17), 4004-4009 (1993-09-01)
The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its injury of cells and induction of diarrhea, without reducing its antitumor activity, was investigated in rats. Oxonic acid was found to
Kei Nishizawa et al.
PloS one, 14(4), e0214862-e0214862 (2019-04-06)
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of
Haruka Fujikawa et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-10)
The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, pharmacological and genetic inhibition
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 156124-5G | 04061835554294 |
| 156124-25G | 04061833416624 |
| 156124-100G | 04061838742469 |