157201
Sodium aurothiomalate hydrate
Synonym(s):
(1,2-Dicarboxyethylthio)gold disodium salt hydrate, Gold sodium thiomalate hydrate, Mercaptobutanedioic acid gold(I) disodium salt
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About This Item
Linear Formula:
NaO2CCH2CH(SAu)CO2Na · xH2O
Molecular Weight:
390.08 (anhydrous basis)
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Form:
powder
form
powder
Quality Level
SMILES string
O.[Na+].[Na+].[O-]C(=O)CC(S[Au])C([O-])=O
InChI
1S/C4H6O4S.Au.2Na.H2O/c5-3(6)1-2(9)4(7)8;;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;;1H2/q;3*+1;/p-3
InChI key
YLQOAPBVYJCTPW-UHFFFAOYSA-K
General description
Sodium aurothiomalate has antirheumatic properties and exhibits inhibitory effects against M. tuberculosis.
Application
Sodium aurothiomalate hydrate was used in the high mobility group box chromosomal protein 1 (HMGB1) western blotting.
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Kathryn E A Lougheed et al.
Tuberculosis (Edinburgh, Scotland), 89(5), 364-370 (2009-08-25)
Mycobacterium tuberculosis has an on-going impact on global public health and new therapeutics to treat tuberculosis are urgently required. The emergence of drug resistant tuberculosis poses a serious threat to the control of this pathogen, and the development of drugs
Cecilia K Zetterström et al.
Journal of leukocyte biology, 83(1), 31-38 (2007-10-05)
Gold compounds such as gold sodium thiomalate (GST) can reduce the symptoms of rheumatoid arthritis (RA), although their mechanism of action is not well defined. As the proinflammatory mediator high mobility group box chromosomal protein 1 (HMGB1) may play a
Meghan Riddell et al.
Nature communications, 9(1), 5357-5357 (2018-12-19)
Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 157201-250MG | 04061838743244 |
| 157201-1G | 04061825894645 |