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Merck
CN

17343

Bromhexine hydrochloride

≥98.0% (AT)

Synonym(s):

2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride, N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride, Bromohexine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H20Br2N2 · HCl
CAS Number:
611-75-6
Molecular Weight:
412.59
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
329751532
EC Number:
210-280-8
Beilstein/REAXYS Number:
4848376
MDL number:
MFCD00056626
Assay:
≥98.0% (AT)
Form:
powder

Key Documents

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InChI key

UCDKONUHZNTQPY-UHFFFAOYSA-N

InChI

1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

SMILES string

Cl.CN(Cc1cc(Br)cc(Br)c1N)C2CCCCC2

assay

≥98.0% (AT)

form

powder

functional group

amine, bromo

Quality Level

100

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Application

Bromhexine hydrochloride was used in the secretion of pancreatic juice of low viscosity.

General description

Bromhexine hydrochloride is a bronchial mucolytic.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBJ8156V
BCBB8827V
BCBB8827
1342515
1147328

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Tatsuhiro Tsujimoto et al.
Alcoholism, clinical and experimental research, 29(12 Suppl), 272S-276S (2005-12-31)
Abstinence is a prerequisite for the treatment of alcoholic chronic pancreatitis, but there are patients who have repeated attacks because of their inability to abstain and the consequent congestive effects of the continued alcohol intake on pancreatic juice. Bromhexine hydrochloride
Mladen Stojanov et al.
International journal of pharmaceutics, 422(1-2), 349-355 (2011-10-27)
Bromhexine hydrochloride (bromhexine) is a mucolytic agent with very low aqueous solubility. However, with addition of cyclodextrins (CD) to the formulation, this disadvantage may be limited and therapeutic doses of bromhexine in solution can be achieved. The interaction of bromhexine
Matthew E Spector et al.
Head & neck, 34(12), 1727-1733 (2012-01-17)
Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis. Seventy-eight previously untreated patients nested in a concurrent chemoradiation protocol were reviewed to correlate
Saman Azodi-Deilami et al.
Applied biochemistry and biotechnology, 164(2), 133-147 (2010-11-16)
Imprinted polymers are now being increasingly considered for active biomedical uses such as drug delivery. In this work, the use of molecularly imprinted polymers (MIPs) in designing new drug delivery devices was studied. Imprinted polymers were prepared from methacrylic acid
Marcello Nicoletti et al.
Natural product research, 24(14), 1325-1329 (2010-08-31)
The utilisation of NMR fingerprinting is proposed as a rapid, available and reliable method to determine the contamination of herbal products. The presence of nimesulide has been reported recently as the contaminant of P.C. 28 Plus, a product based on
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