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Sigma-Aldrich

4-Methoxy-1-naphthol

≥97%

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Synonym(s):
1-Hydroxy-4-methoxynaphthalene
Linear Formula:
CH3OC10H6OH
CAS Number:
84-85-5
Molecular Weight:
174.20
Beilstein:
1818465
EC Number:
201-566-3
MDL number:
MFCD00003976
PubChem Substance ID:
24850485
NACRES:
NA.22

Quality Level

200

Assay

≥97%

form

solid

mp

126-129 °C (lit.)

SMILES string

COc1ccc(O)c2ccccc12

InChI

1S/C11H10O2/c1-13-11-7-6-10(12)8-4-2-3-5-9(8)11/h2-7,12H,1H3

InChI key

BOTGCZBEERTTDQ-UHFFFAOYSA-N

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Application

4-Methoxy-1-naphthol was used in the synthesis of 3-(4-hydroxy-1-naphthoxy)lactic acid (4-HO-NLA).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 - H315 - H319 - H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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R E Talaat et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 202-207 (1986-03-01)
The formation of 3-(4-hydroxy-1-naphthoxy)lactic acid (4-HO-NLA) from propranolol was investigated. Authentic 4-HO-NLA was synthesized from 4-methoxy-1-naphthol using methods previously used for preparation of naphthoxylactic acid (NLA). Cleavage of the 4-methyl ether was accomplished using iodotrimethylsilane in the presence of cyclopentene.
Denilson F Oliveira et al.
Experimental parasitology, 199, 17-23 (2019-02-23)
Exposing second-stage juveniles (J2) of Meloidogyne incognita in vitro to a phenolic compound sometimes fails to cause J2 mortality, but in tests in vivo the same compound may reduce the infectivity and population of the nematode. This work aimed to

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