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177466

4-Methylcyclohexylamine, mixture of cis and trans

Name: 4-Methylcyclohexylamine, mixture of <I>cis</I> and <I>trans</I>
Brand: ALDRICH

97%

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About This Item

Linear Formula:

CH₃C₆H₁₀NH₂

CAS Number:

6321-23-9

Molecular Weight:

113.20

NACRES:

NA.22

PubChem Substance ID:

24850638

UNSPSC Code:

12352100

EC Number:

228-673-8

MDL number:

MFCD00001495

Assay:

97%

Form:

liquid

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Properties

Quality Level

100

assay

97%

form

liquid

refractive index

n20/D 1.4531 (lit.)

bp

151-154 °C (lit.)

density

0.855 g/mL at 25 °C (lit.)

SMILES string

CC1CCC(N)CC1

InChI

1S/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3

InChI key

KSMVBYPXNKCPAJ-UHFFFAOYSA-N

Description

General description

Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.

pictograms

GHS02,GHS05

signalword

Danger

hcodes

H226,H314

pcodes

P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

80.6 °F - closed cup

flash_point_c

27 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Chemoprevention of B-cell lymphomas by inhibition of the Myc target spermidine synthase.

TachaZi Plym Forshell et al.

Cancer prevention research (Philadelphia, Pa.), 3(2), 140-147 (2010-01-28)

The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc

Assay for spermidine synthase activity by micellar electrokinetic chromatography with laser-induced fluorescence detection.

Masatake Sano et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 80-83 (2006-08-26)

An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors. The assay was established by estimating the amount of spermidine

Control of spermidine and spermine levels in rat tissues by trans-4-methylcyclohexylamine, a spermidine-synthase inhibitor.

Masaki Kobayashi et al.

Biological & pharmaceutical bulletin, 28(4), 569-573 (2005-04-02)

In rat tissues, a decrease in spermidine, accompanied by an increase in spermine was induced by the oral administration (once daily for either 1 week or 1 month) of trans-4-methylcyclohexylamine (4MCHA), a spermidine synthase inhibitor. This is similar to the

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Global Trade Item Number

SKU	GTIN
177466-1G	04061838753212
177466-10G	04061836825492