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Merck
CN

180696

Dimethyl 2-oxopropylphosphonate

95%

Synonym(s):

Dimethyl acetonylphosphonate

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About This Item

Linear Formula:
CH3COCH2P(O)(OCH3)2
CAS Number:
Molecular Weight:
166.11
UNSPSC Code:
12352108
NACRES:
NA.22
PubChem Substance ID:
EC Number:
224-110-5
Beilstein/REAXYS Number:
1766218
MDL number:
Assay:
95%
Form:
liquid
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InChI key

UOWIYNWMROWVDG-UHFFFAOYSA-N

InChI

1S/C5H11O4P/c1-5(6)4-10(7,8-2)9-3/h4H2,1-3H3

SMILES string

COP(=O)(CC(C)=O)OC

assay

95%

form

liquid

reaction suitability

reaction type: C-C Bond Formation

refractive index

n20/D 1.439 (lit.)

bp

76-79 °C/3 mmHg (lit.)

density

1.202 g/mL at 25 °C (lit.)

functional group

ketone, phosphonate

Quality Level

Application

Reagent used together with tosyl azide in a one-pot alkynylation of aldehydes.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

200.1 °F - closed cup

flash_point_c

93.4 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Synthesis, 59-59 (2004)
Synthesis, 753-753 (2006)
B Resul et al.
Journal of medicinal chemistry, 36(2), 243-248 (1993-01-22)
A series of phenyl-substituted analogues of prostaglandin F2 alpha (PGF2 alpha) were prepared and evaluated for ocular hypotensive effect and side effects in different animal models. In addition, the activity of the analogues on FP receptors was studied in vitro.

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