183946
6-(Chloromethyl)uracil
98%
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C5H5ClN2O2
CAS Number:
Molecular Weight:
160.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
242-431-9
MDL number:
Assay:
98%
Product Name
6-(Chloromethyl)uracil, 98%
InChI key
VCFXBAPEXBTNEA-UHFFFAOYSA-N
InChI
1S/C5H5ClN2O2/c6-2-3-1-4(9)8-5(10)7-3/h1H,2H2,(H2,7,8,9,10)
SMILES string
ClCC1=CC(=O)NC(=O)N1
assay
98%
mp
257 °C (dec.) (lit.)
Quality Level
Application
6-(Chloromethyl)uracil was used in the synthesis of:
- 5-bromo-6-(chloromethyl)uracil
- pteridine compounds, potential anticancer agents
- substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase
General description
6-(Chloromethyl)uracil on chlorination with sulfuryl chloride in acetic acid yields 5-chloro-6-(chloromethyl)uracil.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Paul E Murray et al.
Bioorganic & medicinal chemistry, 10(3), 525-530 (2002-01-30)
A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the most active. 1-[(5-Chloro-2,4-dihydroxypyrimidin-6-yl)methyl]pyridinium chloride, was identified as the best inhibitor being 5-fold more potent
Shingo Yano et al.
Bioorganic & medicinal chemistry, 12(13), 3431-3441 (2004-06-10)
A series of novel 6-methylene-bridged uracil derivatives have been prepared as inhibitors of human thymidine phosphorylase (TP). To enhance the in vivo antitumor activity of fluorinated pyrimidine 2'-deoxyribonucleosides such as 2'-deoxy-5-(trifluoromethyl)uridine (F(3)dThd), a potent TP inhibitor preventing their degradation to
Prem M S Chauhan et al.
Bioorganic & medicinal chemistry, 13(10), 3513-3518 (2005-04-26)
Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as
J Klosa
Arzneimittel-Forschung, 30(2), 228-231 (1980-01-01)
The synthesis of new uracil derivatives is described. In 4-chloromethyluracil, chlorine can be easily exchanged under mild conditions for amine, aniline, hydrazine, and phenol.
W Wang et al.
International journal of radiation biology, 71(4), 387-399 (1997-04-01)
In this work radicals generated by dissociative electron attachment to iodoacetamide (H2NCOCH2.) and 6-chloromethyluracil (U5CH2.) are suggested to react with DNA nucleotides in frozen aqueous solutions via either hydrogen abstraction or addition to the double bonds of the bases. Methyl
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service