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Merck
CN

191337

1-(4-Fluorophenyl)piperazine

98%

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About This Item

Empirical Formula (Hill Notation):
C10H13FN2
CAS Number:
2252-63-3
Molecular Weight:
180.22
NACRES:
NA.22
PubChem Substance ID:
24851481
UNSPSC Code:
12352100
EC Number:
218-846-6
MDL number:
MFCD00005960

Key Documents

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Product Name

1-(4-Fluorophenyl)piperazine, 98%

InChI key

AVJKDKWRVSSJPK-UHFFFAOYSA-N

InChI

1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

SMILES string

Fc1ccc(cc1)N2CCNCC2

assay

98%

form

solid

drug control

Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
kontrollierte Droge in Deutschland

Quality Level

100

Gene Information

rat ... Chrnb2(54239)

bp

118-123 °C/0.1 mmHg (lit.)

mp

30-33 °C (lit.)

Application

1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
S47598V
S47598
S39551
04221PB
19008HI

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Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist).
Collins M, et al.
Journal of the Chemical Society. Perkin Transactions 1, 23, 3185-3188 (1992)
P E Keane et al.
Neuropharmacology, 21(2), 163-169 (1982-02-01)
Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain
Craig A Stockmeier et al.
Journal of psychiatric research, 43(10), 887-894 (2009-02-14)
Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in depression or suicide, while neuroimaging studies report a decrease in antagonist binding
Camilla Montesano et al.
Drug testing and analysis, 9(5), 798-807 (2016-07-28)
In this paper, an analytical method has been developed and validated for the analysis of new psychoactive substances (NPS) and metabolites in hair samples. The method was based on pressurized liquid extraction (PLE) followed by solid-phase extraction (SPE) clean-up and

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