193232
1,4-Benzodioxan-6-amine
≥98%
Synonym(s):
6-Amino-1,4-benzodioxan
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About This Item
Empirical Formula (Hill Notation):
C8H9NO2
CAS Number:
Molecular Weight:
151.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
244-718-4
MDL number:
Assay:
≥98%
assay
≥98%
refractive index
n20/D 1.599 (lit.)
mp
29-31 °C (lit.)
density
1.231 g/mL (lit.)
SMILES string
Nc1ccc2OCCOc2c1
InChI
1S/C8H9NO2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5H,3-4,9H2
InChI key
BZKOZYWGZKRTIB-UHFFFAOYSA-N
Application
1,4-Benzodioxan-6-amine was used in the synthesis of N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins having anti-tumor activity and dioxanoacridinones.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Ajay Kumar et al.
Journal of heterocyclic chemistry, 47(6), 1275-1282 (2011-01-05)
Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.
2, 3-Dihydrodioxin [2, 3-b] acridin-11 (6H)-one.
Karolak-Wojciechowska J, et al.
Acta Crystallographica Section C, Crystal Structure Communications, 54(11), 1689-1690 (1998)
Elizabeth A Grossman et al.
Cell chemical biology, 24(11), 1368-1376 (2017-09-19)
Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products can enable pharmacological interrogation of these sites
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 193232-10G | 04061838760715 |
| 193232-50G | 04061836825645 |