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196894

4-(Trifluoromethyl)benzoic acid

98%

Synonym(s):

α,α,α-Trifluoro-p-toluic acid, 4-Carboxybenzotrifluoride

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About This Item

Linear Formula:
CF3C6H4CO2H
CAS Number:
455-24-3
Molecular Weight:
190.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24851805
EC Number:
207-242-8
Beilstein/REAXYS Number:
2049241
MDL number:
MFCD00002562
Assay:
98%
Form:
powder
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Quality Level

100

assay

98%

form

powder

mp

219-220 °C (lit.)

functional group

carboxylic acid, fluoro

SMILES string

OC(=O)c1ccc(cc1)C(F)(F)F

InChI

1S/C8H5F3O2/c9-8(10,11)6-3-1-5(2-4-6)7(12)13/h1-4H,(H,12,13)

InChI key

SWKPKONEIZGROQ-UHFFFAOYSA-N

Application

4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via N,N′-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide. It was used as internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX5992
MKCT0355
MKCQ6394
MKCM6472
MKCJ9257

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Total synthesis of the C-1027 chromophore core: extremely facile enediyne formation through Sml2-mediated 1,2-elimination.
Masayuki Inoue et al.
Angewandte Chemie (International ed. in English), 47(9), 1777-1779 (2008-01-24)
Fabio Ziarelli et al.
Journal of pharmaceutical and biomedical analysis, 59, 13-17 (2011-11-08)
This work shows that high resolution magic angle spinning (HR-MAS) can be used to elucidate ligand-receptor binding phenomena for mass-limited samples in liquid solution. With respect to conventional 5mm liquid-state NMR probe heads, HR-MAS allows for a considerable reduction (about
Martin Krátký et al.
Molecules (Basel, Switzerland), 17(8), 9426-9442 (2012-08-09)
Searching for novel antimicrobial agents still represents a current topic in medicinal chemistry. In this study, the synthesis and analytical data of eighteen salicylanilide esters with 4-(trifluoromethyl)benzoic acid are presented. They were assayed in vitro as potential antimycotic agents against
View All Related Papers

Global Trade Item Number

SKUGTIN
196894-5G04061838762276