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196932

3-Methoxy-5-(trifluoromethyl)aniline

Name: 3-Methoxy-5-(trifluoromethyl)aniline
Brand: ALDRICH

99%

Synonym(s):

5-Methoxy-α,α,α-trifluoro-m-toluidine

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About This Item

Linear Formula:

CH₃OC₆H₃(CF₃)NH₂

CAS Number:

349-55-3

Molecular Weight:

191.15

UNSPSC Code:

12352100

PubChem Substance ID:

24851810

EC Number:

206-487-8

MDL number:

MFCD00000393

Assay:

99%

Form:

solid

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Properties

assay

99%

form

solid

mp

50-52 °C (lit.)

functional group

fluoro

SMILES string

COc1cc(N)cc(c1)C(F)(F)F

InChI

1S/C8H8F3NO/c1-13-7-3-5(8(9,10)11)2-6(12)4-7/h2-4H,12H2,1H3

InChI key

VTFGJEYZCUWSAM-UHFFFAOYSA-N

Description

Application

3-Methoxy-5-(trifluoromethyl)aniline was used in the synthesis of spleen tyrosine kinase inhibitors based on the phenylamino pyrimidine thiazole.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H315,H319,H335

pcodes

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).

Luc J Farmer et al.

Bioorganic & medicinal chemistry letters, 18(23), 6231-6235 (2008-10-22)

A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and potent inhibition in mast cell degranulation assays.

Global Trade Item Number

SKU	GTIN
196932-5G	04061832098692