196932
3-Methoxy-5-(trifluoromethyl)aniline
99%
Synonym(s):
5-Methoxy-α,α,α-trifluoro-m-toluidine
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About This Item
Linear Formula:
CH3OC6H3(CF3)NH2
CAS Number:
Molecular Weight:
191.15
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
206-487-8
MDL number:
Assay:
99%
Form:
solid
mp
50-52 °C (lit.)
InChI key
VTFGJEYZCUWSAM-UHFFFAOYSA-N
InChI
1S/C8H8F3NO/c1-13-7-3-5(8(9,10)11)2-6(12)4-7/h2-4H,12H2,1H3
SMILES string
COc1cc(N)cc(c1)C(F)(F)F
assay
99%
form
solid
functional group
fluoro
Application
3-Methoxy-5-(trifluoromethyl)aniline was used in the synthesis of spleen tyrosine kinase inhibitors based on the phenylamino pyrimidine thiazole.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Luc J Farmer et al.
Bioorganic & medicinal chemistry letters, 18(23), 6231-6235 (2008-10-22)
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and potent inhibition in mast cell degranulation assays.
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