199338
1,4-Diamino-2-butanone dihydrochloride
99%
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About This Item
Linear Formula:
H2NCH2CH2COCH2NH2 · 2HCl
CAS Number:
Molecular Weight:
175.06
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
222-914-0
MDL number:
Assay:
99%
InChI key
HDRKYQXFDHZZOW-UHFFFAOYSA-N
InChI
1S/C4H10N2O.2ClH/c5-2-1-4(7)3-6;;/h1-3,5-6H2;2*1H
SMILES string
Cl[H].Cl[H].NCCC(=O)CN
assay
99%
mp
221 °C (dec.) (lit.)
functional group
amine, ketone
Application
1,4-Diamino-2-butanone dihydrochloride was used as a media supplement for the growth of B.pertussis and B. bronchiseptica.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Yukihiro Ueno et al.
Biological & pharmaceutical bulletin, 27(6), 890-892 (2004-06-10)
Candida albicans generally grows in hyphae form in RPMI1640 medium. However, addition of 1,4-diamino-2-butanone (DAB), a competitive inhibitor of ornithine decarboxylase, decreased the amount of polyamines in C. albicans, and induced the proliferation of the C. albicans yeast form. The
A G Tkachenko et al.
Mikrobiologiia, 70(4), 487-494 (2001-09-18)
The level of expression of oxyR, the gene that protects Escherichia coli against oxidative stress, was enhanced by physiological concentrations of the biogenic amine putrescine. This level was directly proportional to the degree of negative DNA supercoiling. 1,4-Diamino-2-butanone (DAB), a
A G Tkachenko et al.
Biochemistry. Biokhimiia, 72(1), 109-116 (2007-02-21)
Mechanisms of antioxidant effect of polyamines were studied in dependence on the strength of superoxide stress. Under conditions of weak stress, polyamines from Escherichia coli cultures were shown to function mainly as a scavenger of free superoxide radicals, whereas under
M Martinez-Pacheco et al.
Archives of microbiology, 151(1), 10-14 (1989-01-01)
Diamino butanone (DAB), a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenomenon. Addition of DAB
Ana F Garcia et al.
Infection and immunity, 73(5), 2602-2610 (2005-04-23)
Trichomonas vaginalis secretes putrescine that is readily detected in vaginal secretions. We wanted to examine the effect of decreased putrescine synthesis by inhibition of ornithine decarboxylase (ODC) on T. vaginalis. One reason is because inhibition of Tritrichomonas foetus ODC results
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