199915
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
97%
Synonym(s):
MPTP
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About This Item
Empirical Formula (Hill Notation):
C12H15N
CAS Number:
Molecular Weight:
173.25
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
97%
Form:
solid
assay
97%
form
solid
drug control
kontrollierte Droge in Deutschland, regulated under CDSA - not available from Sigma-Aldrich Canada
bp
128-132 °C/12 mmHg (lit.)
functional group
phenyl
SMILES string
CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
InChI key
PLRACCBDVIHHLZ-UHFFFAOYSA-N
Biochem/physiol Actions
Dopaminergic neurotoxin.
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Disclaimer
Reportedly causes a severe and irreversible Parkinsonism condition in humans and monkeys. New Engl. J. Med. 1983, 309, 310. Science 1983, 219, 979. ibid. 1984, 224, 1083, 1451. ibid. 1984, 225, 529. J. Med. Chem. 1985, 28, 997.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 1
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
Regulatory Information
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Qi-Shun Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 153-159 (2016-10-25)
Numerous long non-coding RNAs (lncRNA) have been identified in neurodegenerative disorders including Parkinson's disease (PD). Emerging evidence demonstrates that β-asarone functions as neuroprotective effects in both in vitro and in vivo models. However, the role of β-asarone and its potential
Yan Liu et al.
Aging, 11(14), 5008-5034 (2019-07-18)
Parkinson's disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such as cognitive impairment, and malfunction of gamma-aminobutyric acid (GABA) mediated inhibitory transmission plays an important role in PD pathogenesis. The ginsenoside Rb1 molecule, a
Adjia Hamadjida et al.
Journal of neural transmission (Vienna, Austria : 1996), 125(9), 1355-1360 (2017-12-17)
Trazodone is a clinically available anti-depressant that exhibits affinity for serotonin 1A and 2A receptors, as well as for alpha-adrenoceptors, suggesting that it may be useful to treat L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia and psychosis that are encountered in advanced Parkinson's disease