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Merck
CN

219746

DL-Homocysteic acid

97%

Synonym(s):

DL-2-Amino-4-sulfobutyric acid

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About This Item

Linear Formula:
HO3SCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
183.18
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
207-991-0
MDL number:
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Product Name

DL-Homocysteic acid, 97%

InChI key

VBOQYPQEPHKASR-UHFFFAOYSA-N

InChI

1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)

SMILES string

NC(CCS(O)(=O)=O)C(O)=O

assay

97%

form

solid

mp

273 °C (dec.) (lit.)

solubility

water: soluble 50 mg/mL, clear to slightly hazy, colorless to yellow

functional group

amine
carboxylic acid
sulfonic acid

General description

Complexes of DL-homocysteic acid with Na+, Cu2+, Zn2+ and Ni2+ has been synthesized. DL-Homocysteic acid induces oxidative stress in brain of immature rats.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Hui-Zhen Jia et al.
Guang pu xue yu guang pu fen xi = Guang pu, 27(7), 1291-1294 (2007-10-20)
The complexes of DL-homocysteic acid (DLH) with Na+, Cu2+, Zn2+ and Ni2+ were synthesized and elemental analyses were used to detect the compositions of these complexes. FTIR spectroscopy was employed to study these coordination structures. The results indicated that all
Glauber S F da Silva et al.
Frontiers in physiology, 8, 452-452 (2017-07-18)
Hydrogen Sulfide (H
Jaroslava Folbergrová et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(2), 123-130 (2012-12-15)
We have recently demonstrated the evidence of oxidative stress in brain of immature rats during seizures induced by DL-homocysteic acid (DL-HCA). The aim of the present study was to investigate the antioxidant defense mechanisms under these conditions. Seizures were induced
Asya Makhro et al.
American journal of physiology. Cell physiology, 298(6), C1315-C1325 (2010-05-12)
N-methyl-d-aspartate (NMDA) receptors are ligand-gated nonselective cation channels mediating fast neuronal transmission and long-term potentiation in the central nervous system. These channels have a 10-fold higher permeability for Ca(2+) compared with Na(+) or K(+) and binding of the agonists (glutamate
Kyle V Butler et al.
Journal of the American Chemical Society, 132(31), 10842-10846 (2010-07-10)
Structure-based drug design combined with homology modeling techniques were used to develop potent inhibitors of HDAC6 that display superior selectivity for the HDAC6 isozyme compared to other inhibitors. These inhibitors can be assembled in a few synthetic steps, and thus

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