222569
Fomepizole
99%
Synonym(s):
4-Methylpyrazole
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About This Item
Empirical Formula (Hill Notation):
C4H6N2
CAS Number:
Molecular Weight:
82.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
231-445-0
Beilstein/REAXYS Number:
105204
MDL number:
Assay:
99%
assay
99%
refractive index
n20/D 1.495 (lit.)
bp
99-100 °C/6 mmHg (lit.)
solubility
alcohol: soluble(lit.), water: soluble(lit.)
density
0.993 g/mL at 25 °C (lit.)
SMILES string
Cc1cn[nH]c1
InChI
1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChI key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126)
General description
4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.
Application
Fomepizole (4-Methylpyrazole) can be used as:
- A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
- A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
- A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.
Useful as an antidote in methanol and ethylene glycol poisoning.
Biochem/physiol Actions
Alcohol dehydrogenase inhibitor
Alcohol dehydrogenase inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
204.8 °F - closed cup
flash_point_c
96 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
Jafar Shahraki et al.
Iranian journal of pharmaceutical research : IJPR, 12(4), 829-844 (2014-02-14)
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes
Marisa Battistella
The Annals of pharmacotherapy, 36(6), 1085-1089 (2002-05-23)
To assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis. A MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 222569-5G | 04061838090041 |
| 222569-1G | 04061838096531 |