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Merck
CN

224529

3-Chloro-4-hydroxyphenylacetic acid

99%

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About This Item

Linear Formula:
ClC6H3(OH)CH2CO2H
CAS Number:
Molecular Weight:
186.59
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
251-643-0
MDL number:
Assay:
99%
Form:
powder
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Quality Level

assay

99%

form

powder

mp

108-110 °C (lit.)

functional group

carboxylic acid, chloro

SMILES string

OC(=O)Cc1ccc(O)c(Cl)c1

InChI

1S/C8H7ClO3/c9-6-3-5(4-8(11)12)1-2-7(6)10/h1-3,10H,4H2,(H,11,12)

InChI key

IYTUKSIOQKTZEG-UHFFFAOYSA-N

General description

3-Chloro-4-hydroxyphenylacetic acid is an auxin influx inhibitor. It is one of the major chlorinated metabolite of chlorotyrosine.


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Petr Hosek et al.
Journal of experimental botany, 63(10), 3815-3827 (2012-03-23)
The molecular basis of cellular auxin transport is still not fully understood. Although a number of carriers have been identified and proved to be involved in auxin transport, their regulation and possible activity of as yet unknown transporters remain unclear.
Ali R Mani et al.
The Journal of biological chemistry, 282(40), 29114-29121 (2007-08-10)
During inflammation, neutrophil- and monocyte-derived myeloperoxidase catalyzes the formation of hypochlorous acid, which can chlorinate tyrosine residues in proteins to form chlorotyrosine. However, little is known of the metabolism and disposition of chlorotyrosine in vivo. Following infusion of deuterium-labeled [D(4)]chlorotyrosine
H Nguyen et al.
Toxicology, 160(1-3), 207-217 (2001-03-14)
Exposure to airborne pollutants such as tobacco smoke is associated with increased activation of inflammatory-immune processes and is thought to contribute to the incidence of respiratory tract disease. We hypothezised that cigarette smoke (CS) could synergize with activated inflammatory/immune cells



Global Trade Item Number

SKUGTIN
224529-25G04061831819137
224529-100G04061831838169