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228583

Sigma-Aldrich

3-Chloro-4-fluoroaniline

98%

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Linear Formula:
ClC6H3(F)NH2
CAS Number:
367-21-5
Molecular Weight:
145.56
Beilstein:
1562786
EC Number:
206-682-8
MDL number:
MFCD00007767
PubChem Substance ID:
24853696
NACRES:
NA.22

Quality Level

100

Assay

98%

bp

227-228 °C (lit.)

mp

42-44 °C (lit.)

SMILES string

Nc1ccc(F)c(Cl)c1

InChI

1S/C6H5ClFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2

InChI key

YSEMCVGMNUUNRK-UHFFFAOYSA-N

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General description

The exposure of workers to 3-chloro-4-fluoroaniline (CFA) was monitored by an HPLC method.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301 + H311 + H331 - H373

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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C J Duckett et al.
Xenobiotica; the fate of foreign compounds in biological systems, 36(1), 59-77 (2006-03-02)
The metabolic fate of 3-chloro-4-fluoroaniline was investigated in rat following intraperitoneal (i.p.) administration at 5 and 50 mg kg(-1) using a combination of HPLC-MS, HPLC-MS/MS, (19)F-NMR spectroscopy, HPLC-NMR spectroscopy and high-pressure liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) with (35)Cl
M K Baldwin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 10(2), 135-144 (1980-02-01)
1. 3-Chloro-4-fluorol[14C]aniline, orally administered to a female dog (0.135 mg/kg), was eliminated in the urine as 2-amino-4-chloro-5-fluorophenyl sulphate (83% in 48 h). 2. When 3-chloro-4-fluoro[14C]aniline was administered orally to male rats (ca 2.3 mg/kg), the 0-24 h urine contained 2-amino-4-chloro-5-fluorophenyl
C V Eadsforth et al.
Journal of analytical toxicology, 12(6), 330-333 (1988-11-01)
An HPLC method for monitoring exposure of workers to 3-chloro-4-fluoroaniline (CFA) is described. It is based on the detection of a major urinary metabolite, 2-amino-4-chloro-5-fluorophenyl sulphate, and is superior to the previously adopted GC method. The limit of detection for
P J Boogaard et al.
Environmental health perspectives, 102 Suppl 6, 23-25 (1994-10-01)
In two studies, involving 75 and 72 workers, potential exposure to 3-chloro-4-fluoroaniline (CFA) was biologically monitored by determination of its main urinary metabolite 2-amino-4-chloro-5-fluorophenol sulfate (CFA-S). As this method only allows the detection of recent exposure, analysis of CFA adducts
Vasili Travkin et al.
FEMS microbiology letters, 209(2), 307-312 (2002-05-15)
In this paper we report the isolation and characterization of an anaerobic enrichment culture as well as of a Rhodococcus sp. strain 2 capable of degrading 3,4-dihaloanilines under nitrate reducing conditions. Using mass spectrometry several of the intermediates formed in

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