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228818

Diethyl propylmalonate

Name: Diethyl propylmalonate
Brand: ALDRICH

99%

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About This Item

Linear Formula:

CH₃CH₂CH₂CH(COOC₂H₅)₂

CAS Number:

2163-48-6

Molecular Weight:

202.25

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24853714

EC Number:

218-492-2

Beilstein/REAXYS Number:

510157

MDL number:

MFCD00009168

Assay:

99%

Form:

liquid

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Properties

assay

99%

form

liquid

refractive index

n20/D 1.418 (lit.)

bp

221-222 °C (lit.)

density

0.987 g/mL at 25 °C (lit.)

SMILES string

CCCC(C(=O)OCC)C(=O)OCC

InChI

1S/C10H18O4/c1-4-7-8(9(11)13-5-2)10(12)14-6-3/h8H,4-7H2,1-3H3

InChI key

GRRSDGHTSMJICM-UHFFFAOYSA-N

Description

Application

Diethyl propylmalonate was used in the synthesis of propylacrylic acid (PAA).

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

197.6 °F - closed cup

flash_point_c

92 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Rational design of composition and activity correlations for pH-responsive and glutathione-reactive polymer therapeutics.

Mohamed E H El-Sayed et al.

Journal of controlled release : official journal of the Controlled Release Society, 104(2), 417-427 (2005-06-29)

Limited cytoplasmic delivery of enzyme-susceptible drugs remains a significant challenge facing the development of protein and nucleic acid therapies that act in intracellular compartments. "Smart" pH-responsive, membrane-destabilizing polymers present a new approach to shuttling therapeutic molecules past the endosomal membrane

Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue.

Kyle M Hocking et al.

Tissue engineering. Part A, 25(5-6), 416-426 (2018-08-23)

Subarachnoid hemorrhage (SAH) is associated with vasospasm that is refractory to traditional vasodilators, and inhibition of vasospasm after SAH remains a large unmet clinical need. SAH causes changes in the phosphorylation state of the small heat shock proteins (HSPs), HSP20

Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines.

Feng Qiu et al.

Biomaterials, 182, 82-91 (2018-08-15)

Cancer vaccines targeting patient-specific tumor neoantigens have recently emerged as a promising component of the rapidly expanding immunotherapeutic armamentarium. However, neoantigenic peptides typically elicit weak CD8+ T cell responses, and so there is a need for universally applicable vaccine delivery

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Global Trade Item Number

SKU	GTIN
228818-5G	04061838781505