236284
2-Nitroanisole
≥99%
Synonym(s):
1-Methoxy-2-nitrobenzene
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About This Item
Linear Formula:
O2NC6H4OCH3
CAS Number:
Molecular Weight:
153.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-052-1
Beilstein/REAXYS Number:
1868032
MDL number:
Assay:
≥99%
Form:
liquid
Quality Level
assay
≥99%
form
liquid
refractive index
n20/D 1.561 (lit.)
bp
273 °C (lit.)
mp
9-12 °C (lit.)
solubility
alcohol: soluble(lit.), diethyl ether: soluble(lit.), water: insoluble(lit.)
density
1.254 g/mL at 25 °C (lit.)
functional group
nitro
SMILES string
COc1ccccc1[N+]([O-])=O
InChI
1S/C7H7NO3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3
InChI key
CFBYEGUGFPZCNF-UHFFFAOYSA-N
General description
2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.
Application
2-Nitroanisole has been employed as solvatochromic probe to examine cybotactic region of pure and mixed supercritical fluid solvent systems.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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M J Miller et al.
Drug metabolism and disposition: the biological fate of chemicals, 13(5), 527-531 (1985-09-01)
The pharmacokinetics and metabolism of o-nitroanisole (ONA) were studied in male Fischer 344 rats. Three dose levels of [14C]ONA (5.0, 50, or 500 mg/kg) were administered orally to rats and daily excreta were analyzed for 14C. Since the highest dose
Y Miura et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 100(2), 249-252 (1991-01-01)
1. The cytochrome P-450 content (0.75 +/- 0.13 nmol/mg microsomal protein) in musk shrew (suncus, Suncus murinus) liver microsomes was lower than that (1.30 +/- 0.26) in rat liver microsomes, but it is approximately the same level as in the
Markéta Miksanová et al.
Chemical research in toxicology, 17(5), 663-671 (2004-05-18)
2-Nitroanisole (2-NA) is an important industrial pollutant and a potent carcinogen for rodents. Determining the capability of humans to metabolize 2-NA and understanding which human cytochrome P450 (P450) enzymes are involved in its activation and/or detoxification are important to assess
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 455377-1G | 04061836685485 |
| 236284-100G | 04061836825928 |