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Merck
CN

246379

Azelaic acid

98%

Synonym(s):

Nonanedioic acid

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About This Item

Linear Formula:
HO2C(CH2)7CO2H
CAS Number:
Molecular Weight:
188.22
UNSPSC Code:
12162002
NACRES:
NA.23
PubChem Substance ID:
EC Number:
204-669-1
Beilstein/REAXYS Number:
1101094
MDL number:
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Product Name

Azelaic acid, 98%

InChI key

BDJRBEYXGGNYIS-UHFFFAOYSA-N

InChI

1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

SMILES string

OC(=O)CCCCCCCC(O)=O

vapor density

6.5 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

assay

98%

form

powder

bp

286 °C/100 mmHg (lit.)

mp

109-111 °C (lit.)

Quality Level

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Application

Azelaic acid can be used:
  • As a bio-based monomer in the development of biodegradable polymers. These polymers are explored for a range of applications, including packaging materials, agricultural films, and other products where biodegradability is a key requirement.
  • As a crucial component in the synthesis of biodegradable copolyester plasticizers for PVC applications.
  • As a monomer in the synthesizing poly(glycerol azelaic acid) for tissue engineering applications. Its contributions to biocompatibility, mechanical properties, degradation behavior, and hydrophilicity make it an essential building block for developing advanced biomaterials aimed at enhancing tissue regeneration processes. In drug delivery systems, azelaic acid may play a role in the synthesis of polymers or other compounds used in drug delivery, potentially enhancing medication effectiveness through improved solubility or stability.
  • In skincare products.

General description

Azelaic acid is an important monomer in the synthesis of various polymers. The presence of two carboxylic acid groups enables azelaic acid to act as a monomer for polycondensation reactions, leading to the formation of polyesters and other polymeric materials. Additionally, it is also used to prepare azelaic acid-based plasticizers to improve the mechanical properties of PVC, making them suitable for various applications, including films, coatings, and flexible products.

signalword

Warning

hcodes

pictograms

Exclamation mark

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

410.0 °F - closed cup

flash_point_c

210 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)


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Seyed Dariush Taherzade et al.
Nanomaterials (Basel, Switzerland), 10(12) (2020-12-02)
Combined therapies emerge as an interesting tool to overcome limitations of traditional pharmacological treatments (efficiency, side effects). Among other materials, metal-organic frameworks (MOFs) offer versatilities for the accommodation of multiple and complementary active pharmaceutical ingredients (APIs): accessible large porosity, availability
Chaemyeong Lee et al.
Scientific reports, 7(1), 13797-13797 (2017-10-25)
Inspired by adhesive mussel proteins, nanospherical self-assemblies were prepared from bolaamphiphiles containing 3,4-dihydroxyphenylalanine (DOPA) moieties, and a suspension of the bolaamphiphile assemblies was used for the preparation of a patterned surface that enhanced cell adhesion and viability. The abundant surface-exposed
Alvin B Coda et al.
Journal of the American Academy of Dermatology, 69(4), 570-577 (2013-07-23)
Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea. We sought to evaluate the effects of azelaic acid (AzA) on these elements of the innate immune system. Gene expression and protease
Esther J van Zuuren et al.
The Cochrane database of systematic reviews, (3)(3), CD003262-CD003262 (2011-03-18)
Rosacea is a common chronic skin condition affecting the face, characterised by flushing, redness, pimples, pustules, and dilated blood vessels. The eyes are often involved and thickening of the skin with enlargement (phymas), especially of the nose, can occur in
Vaneeta M Sheth et al.
Journal of the American Academy of Dermatology, 65(4), 699-714 (2011-09-17)
Several methods of treatment are available to patients with melasma. First-line therapy usually consists of topical compounds that affect the pigment production pathway, broad-spectrum photoprotection, and camouflage. Second-line therapy often consists of the addition of chemical peels, although these must

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