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Merck
CN

247480

Domiphen bromide

97%, powder

Synonym(s):

(Dodecyldimethyl-2-phenoxyethyl)ammonium bromide

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About This Item

Linear Formula:
CH3(CH2)11N(CH3)2(CH2CH2OC6H5)Br
CAS Number:
538-71-6
Molecular Weight:
414.46
NACRES:
NA.22
PubChem Substance ID:
24854870
UNSPSC Code:
12352112
EC Number:
208-702-0
MDL number:
MFCD00011769

Key Documents

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Product Name

Domiphen bromide, 97%

InChI key

OJIYIVCMRYCWSE-UHFFFAOYSA-M

InChI

1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1

SMILES string

[Br-].CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1

assay

97%

form

powder

mp

117-119 °C (lit.)

Quality Level

100

General description

Domiphen bromide (DMP) is a quaternary ammonium compound that belongs to the class of phenol ethers. It can be used as a cationic surfactant.

Application

  • Domiphen Bromide in Antimicrobial Applications: A clinical trial assessed the effectiveness of a mouthwash containing Domiphen Bromide among other quaternary ammonium compounds, showcasing its ability to significantly reduce gingivitis, supporting its use in dental health products (Rosa and Sturzenberger, 1976).
  • Toxicity and Safety Profile of Domiphen Bromide: A recent study explored the proarrhythmic effects induced by Domiphen Bromide in both in vitro and in vivo models, providing vital safety information crucial for its use in pharmaceutical applications (Long et al., 2021).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBK7486
STBK7487
STBK5753
STBK3823
STBK1907

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F Scaglione et al.
International journal of clinical pharmacology research, 3(5), 357-361 (1983-01-01)
Thirty-one patients (21 M and 10 F), affected by acute infectious dental disease, were treated with domifen bromide (A) or placebo (Pl). It was found that A had a beneficial effect on the results of clinical controls and reduced the
F Scaglione et al.
International journal of clinical pharmacology research, 3(4), 261-264 (1983-01-01)
By means of a double blind, placebo controlled trial, we have studied 29 patients (14 M and 15 F) affected by different acute infectious oral diseases. Our results suggest that domifen bromide may be useful in treating infectious oral diseases
[Antiseptic activity of domiphen bromide on the yeast Candida in the mouth].
P Goumas et al.
Stomatologia, 41(5), 249-257 (1984-09-01)
Peng Gao et al.
European journal of pharmacology, 694(1-3), 45-52 (2012-09-15)
Tuberculosis is a serious threat to world-wide public health usually caused in humans by Mycobacterium tuberculosis (M. tuberculosis). It exclusively utilizes the methylerythritol phosphate (MEP) pathway for biosynthesis of isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), the precursors
Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures
Majid Q, et al.
Journal of Chemical and Engineering Data, 67(10), 2974-2985 (2022)
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