247480
度米芬
97%, powder
别名:
十二烷基-二甲基-2-苯氧基-乙基溴化铵
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关于此项目
线性分子式:
CH3(CH2)11N(CH3)2(CH2CH2OC6H5)Br
化学文摘社编号:
分子量:
414.46
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352112
EC Number:
208-702-0
MDL number:
产品名称
度米芬, 97%
InChI key
OJIYIVCMRYCWSE-UHFFFAOYSA-M
InChI
1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1
SMILES string
[Br-].CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1
assay
97%
form
powder
mp
117-119 °C (lit.)
Quality Level
Application
- 多菲芬在抗菌方面的应用：一项临床试验评估了含多芬溴化剂和其他季铵化合物的漱口水的有效性，显示其能够显著减少牙龈炎，支持其在牙科保健产品中的使用（Rosa and Sturzenberger, 1976）。
- 多菲芬溴化剂的毒性和安全性研究：最近的一项研究探索了多菲芬在体外和体内模型中诱导的促心律失常效应，为其在制药应用中的应用提供了至关重要的安全性信息（Long et al., 2021）。
General description
度米芬(DMP)是一种季铵盐化合物，属于苯酚醚类物质。可用作阳离子表面活性剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Lorenzo H Chen et al.
Journal of pharmaceutical and biomedical analysis, 40(4), 964-970 (2005-10-26)
This report describes a rapid and accurate reversed phase HPLC method for the simultaneous quantitation of multiple surfactants in various bioprocess solution matrices including cell lysates. Separation and quantitation of a mixture of the cationic detergent domiphen bromide from the
[Antiseptic activity of domiphen bromide on the yeast Candida in the mouth].
P Goumas et al.
Stomatologia, 41(5), 249-257 (1984-09-01)
F Scaglione et al.
International journal of clinical pharmacology research, 3(4), 261-264 (1983-01-01)
By means of a double blind, placebo controlled trial, we have studied 29 patients (14 M and 15 F) affected by different acute infectious oral diseases. Our results suggest that domifen bromide may be useful in treating infectious oral diseases
F Scaglione et al.
International journal of clinical pharmacology research, 3(5), 357-361 (1983-01-01)
Thirty-one patients (21 M and 10 F), affected by acute infectious dental disease, were treated with domifen bromide (A) or placebo (Pl). It was found that A had a beneficial effect on the results of clinical controls and reduced the
Peng Gao et al.
European journal of pharmacology, 694(1-3), 45-52 (2012-09-15)
Tuberculosis is a serious threat to world-wide public health usually caused in humans by Mycobacterium tuberculosis (M. tuberculosis). It exclusively utilizes the methylerythritol phosphate (MEP) pathway for biosynthesis of isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), the precursors
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