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About This Item
Empirical Formula (Hill Notation):
C8H14O4
CAS Number:
Molecular Weight:
174.19
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
226-159-8
Beilstein/REAXYS Number:
80854
MDL number:
Product Name
Isosorbide dimethyl ether, 98%
InChI key
MEJYDZQQVZJMPP-ULAWRXDQSA-N
InChI
1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1
SMILES string
CO[C@H]1COC2[C@@H](COC12)OC
assay
98%
form
liquid
optical activity
[α]21/D +96.1°, c = 2 in chloroform
refractive index
n20/D 1.461 (lit.)
bp
93-95 °C/0.1 mmHg (lit.)
density
1.15 g/mL at 25 °C (lit.)
Quality Level
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Application
Isosorbide dimethyl ether (DMI), a sustainable solvent, is widely used in various cosmetic and pharmaceutical formulations.
General applications:
General applications:
- DMI can be used as an alternative green solvent for epoxidation of cyclooctene, Baylis–Hillman reaction of isomaltulose-derived aldehydes with α,β-unsaturated ketones and also in solid-phase synthesis.
- It can be used as a coalescent for water-borne paints, where it acts as a co-solvent during the water loss phase and as a coalescing agent during the film formation.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
240.8 °F - closed cup
flash_point_c
116 °C - closed cup
ppe
Eyeshields, Gloves
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E Squillante et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 46(3), 265-271 (1999-01-14)
The in vitro percutaneous fluxes of propylene glycol (PG), cis-oleic acid (OA) and dimethyl isosorbide (DI) were determined and their effect on nifedipine (N) flux and lag time evaluated. PG, OA and DI flux through hairless mouse (HM) skin was
Greener solvents for solid-phase synthesis.
Lawrenson S, et al.
Green Chemistry, 19(4), 952-962 (2017)
Adrian P Funke et al.
Pharmaceutical research, 19(5), 661-668 (2002-06-19)
Highly lipophilic basic drugs, the antiestrogens AE 1 (log P = 5.82) and AE 2 (log P = 7.8) shall be delivered transdermally. Transdermal permeation of drugs, enhancers, and solvents from various fluid formulations were characterized by in-vitro permeation studies
Bola D Majekodunmi et al.
Pharmaceutical development and technology, 12(6), 609-620 (2007-12-29)
The chemical stability of benzoyl peroxide (BPO) was studied in solutions and gels. The solutions (1% w/v) were prepared in single solvents (alcohol USP, isopropyl alcohol USP, ethyl benzoate, C12-15 alkyl benzoate, dimethyl isosorbide, propylene carbonate, and acetone) and in
H Zia et al.
Pharmaceutical research, 8(4), 502-504 (1991-04-01)
Dimethyl isosorbide (DMI), which is currently under investigation for its potential use as a pharmaceutical vehicle and drug permeation enhancer, is a water-miscible liquid with relatively low viscosity. The solubilization behavior of DMI as a cosolvent for nonpolar drugs was
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