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Merck
CN

248509

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution

0.1 M in methylene chloride

Synonym(s):

(S)-(−)-N-(Trifluoroacetyl)prolyl chloride solution, TPC

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About This Item

Empirical Formula (Hill Notation):
C7H7ClF3NO2
CAS Number:
36724-68-2
Molecular Weight:
229.58
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
24854932
MDL number:
MFCD00010418
Beilstein/REAXYS Number:
480791

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InChI

1S/C7H7ClF3NO2/c8-5(13)4-2-1-3-12(4)6(14)7(9,10)11/h4H,1-3H2/t4-/m0/s1

SMILES string

FC(F)(F)C(=O)N1CCC[C@H]1C(Cl)=O

InChI key

NUOYJPPISCCYDH-BYPYZUCNSA-N

optical purity

ee: 95% (GLC)

concentration

0.1 M in methylene chloride

refractive index

n20/D 1.424

density

1.308 g/mL at 25 °C

functional group

acyl chloride, fluoro

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride can be used as a chiral derivatization reagent:
  • In the chiral separation of psychoactive, cathinone- and amphetamine-related drugs using GC-MS technique.
  • In the estimation of cathinone related drug enantiomers in biological samples like urine and plasma using GC-MS technique.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8194
MKCN9046
MKCN5801
MKCM0286
MKCL0669

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Y Du et al.
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Qiao Feng Tao et al.
Journal of biochemical and biophysical methods, 54(1-3), 103-113 (2003-01-25)
Several important chiral phenethylamine agents such as mexiletine, fenfluramine, amphetamine, methamphetamine and N-n-propylamphetamine show stereoselective disposition in humans and large differences in therapeutic relevance and toxicity. To analyze the enantiomers of chiral amine drugs, stereoselective methods were developed to separate
Luis M Valor et al.
PloS one, 12(8), e0183264-e0183264 (2017-08-18)
Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation process. To characterize the transition of BC into PC, transcriptomes from human naïve BC were compared to those of three functionally-different subsets of human in vivo-generated
Simultaneous quantitative determination of synthetic cathinone enantiomers in urine and plasma using GC-NCI-MS
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Journal of Analytical Methods in Chemistry, 2018 (2018)
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Journal of neuroscience research, 96(2), 194-206 (2017-04-19)
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