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Merck
CN

254886

6,7-Dimethoxycoumarin

98%

Synonym(s):

6,7-Dimethylesculetin, O-Methylisoscopoletin, O-Methylscopoletin, Aesculetin dimethyl ether, Escoparone, Esculetin 6,7-dimethyl ether, Scoparone, Scopoletin methyl ether

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About This Item

Empirical Formula (Hill Notation):
C11H10O4
CAS Number:
120-08-1
Molecular Weight:
206.19
NACRES:
NA.22
PubChem Substance ID:
24855271
UNSPSC Code:
12352100
EC Number:
204-369-0
MDL number:
MFCD00006871

Key Documents

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Product Name

6,7-Dimethoxycoumarin, 98%

InChI key

GUAFOGOEJLSQBT-UHFFFAOYSA-N

InChI

1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

SMILES string

COc1cc2OC(=O)C=Cc2cc1OC

assay

98%

form

powder

mp

143-145 °C (lit.)

functional group

ester

Quality Level

200

Gene Information

mouse ... Maoa(17161)
rat ... Aldh1a2(116676)

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Related Categories

General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL2777
STBK2159
STBH2509
STBH5675
STBH4841

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Jung-Ran Noh et al.
Food chemistry, 141(2), 723-730 (2013-06-26)
This study was performed to investigate the effect of scoparone on the differentiation of 3T3-L1 preadipocytes. Scoparone inhibited triglyceride (TG) accumulation in the mature adipocytes, evidenced by Oil-red O staining and intracellular quantification. Real time-PCR analysis showed that scoparone significantly
Jung-Ran Noh et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(11), 3177-3183 (2010-08-25)
The antioxidant effects of chestnut inner shell extract (CISE) were investigated in a tert-butylhydroperoxide (t-BHP)-treated HepG2 cells, and in mice that were administered carbon tetrachloride (CCl(4)) and fed a high-fat diet (HFD). Pre-incubation with CISE significantly blocked the oxidative stress
Ping-Chung Kuo et al.
Archives of pharmacal research, 34(5), 715-722 (2011-06-10)
In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the
Zhi-guo Yu et al.
Journal of chromatographic science, 45(8), 544-548 (2007-11-21)
A simple and sensitive reversed-phase high-performance liquid chromatography method with UV detection is developed and validated for the determination of 6,7-dimethoxycoumarin in rat plasma and comparative analysis of its pharmacokinetics after intragastric administration of 6,7-dimethoxycoumarin and three different decoctions of
Dongfang Yang et al.
British journal of pharmacology, 164(5), 1547-1557 (2011-06-09)
Hyperbilirubinaemia and cholestasis are two major forms of liver abnormality. The Chinese herb Yin Chin has been used for thousands of years to treat liver dysfunctions. In mice, this herb and its principal ingredient scoparone were found to accelerate the
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