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Merck
CN

254886

6,7-Dimethoxycoumarin

98%

Synonym(s):

6,7-Dimethylesculetin, O-Methylisoscopoletin, O-Methylscopoletin, Aesculetin dimethyl ether, Escoparone, Esculetin 6,7-dimethyl ether, Scoparone, Scopoletin methyl ether

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About This Item

Empirical Formula (Hill Notation):
C11H10O4
CAS Number:
120-08-1
Molecular Weight:
206.19
NACRES:
NA.22
PubChem Substance ID:
24855271
UNSPSC Code:
12352100
EC Number:
204-369-0
MDL number:
MFCD00006871
Assay:
98%
Form:
powder

Key Documents

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InChI key

GUAFOGOEJLSQBT-UHFFFAOYSA-N

InChI

1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

SMILES string

COc1cc2OC(=O)C=Cc2cc1OC

assay

98%

form

powder

mp

143-145 °C (lit.)

functional group

ester

Quality Level

200

Gene Information

mouse ... Maoa(17161)
rat ... Aldh1a2(116676)

Related Categories

General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL2777
STBK2159
STBH2509
STBH5675
STBH4841

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Yoo Jung Yang et al.
Neuroscience letters, 440(1), 14-18 (2008-06-13)
The neurite outgrowth-promoting effects of scoparone isolated from the stem bark of Liriodendron tulipifera were investigated in PC12 cells. At a concentration of 200 microM, scoparone markedly induced neurite outgrowth from PC12 cells. Scoparone at 200 microM also enhanced the
Seung Hyo Jung et al.
Journal of the science of food and agriculture, 99(9), 4397-4406 (2019-03-13)
Compounds of the inner shell of chestnut (Castanea crenata) have diverse biological activities, including anti-cancer and anti-oxidant activities. Here we explored the effects of an extract of chestnut inner shells and of its bioactive component scoparone on vascular smooth muscle
Haitao Lv et al.
Journal of separation science, 31(4), 659-666 (2008-02-12)
A simple, sensitive, and validated method was developed for simultaneous determination of scoparone, capillarisin, rhein, and emodin in rat urine by ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC-MS). The urinary samples were analyzed on an Acquity UPLC BEH
Song Yi Lee et al.
Evidence-based complementary and alternative medicine : eCAM, 2018, 3610494-3610494 (2018-09-14)
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and
Quanwei Yin et al.
Fitoterapia, 83(4), 795-800 (2012-04-03)
Scoparone is an important constituent of Yinchenhao (Artemisia annua L.), a famous Chinese medicinal plant, and has several known bioactivities, and displayed bright prospects in prevention and therapy of jaundice and liver disorders. The aim of this study was to
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