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Merck
CN

258385

Protoporphyrin IX disodium salt

≥90% (HPLC)

Synonym(s):

3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid disodium salt, Depocolin-S, Ooporphyrin disodium salt

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About This Item

Empirical Formula (Hill Notation):
C34H32N4Na2O4
CAS Number:
50865-01-5
Molecular Weight:
606.62
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
24855640
EC Number:
256-815-9
Beilstein/REAXYS Number:
5227034
MDL number:
MFCD00151108

Key Documents

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Product Name

Protoporphyrin IX disodium salt, ≥90% (HPLC)

InChI key

JZRNDUPVNXWZDY-HXFTUNQESA-L

InChI

1S/C34H34N4O4.2Na/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16,36-37H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);;/q;2*+1/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

SMILES string

[Na+].[Na+].Cc1c(CCC([O-])=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC([O-])=O

assay

≥90% (HPLC)

form

powder

λmax

406 nm

storage temp.

2-8°C

Quality Level

200

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Application

Protoporphyrin disodium salt (PpIX) was used as a dye content for fluorescence spectroscopic characterization in a study. The cytotoxic effect of PpIX on sarcoma 180 solid tumors cells was reported in a study.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9723
MKCX7527
MKCV9066
MKCV2630
MKCR6011

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Kana Unuma et al.
PloS one, 8(2), e56526-e56526 (2013-03-05)
Lipopolysaccharide (LPS)-induced myocardial dysfunction is caused, at least in part, by mitochondrial dysfunction. Mitochondrial dysfunction and the oxidative damage associated with it are scavenged through various cellular defense systems such as autophagy to prevent harmful effects. Our recent study has
Filipa L Sousa et al.
Genome biology and evolution, 5(1), 200-216 (2012-12-22)
An open question regarding the evolution of photosynthesis is how cyanobacteria came to possess the two reaction center (RC) types, Type I reaction center (RCI) and Type II reaction center (RCII). The two main competing theories in the foreground of
Pan Wang et al.
Ultrasonics, 53(5), 935-942 (2013-02-19)
Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in
Woo Hyung Lee et al.
Chemico-biological interactions, 204(1), 49-57 (2013-04-30)
Porphyrins are used for photodynamic therapy for their light-absorbing properties, and some of them were approved for the treatment of certain types of cancers. Porphyrins prevent activation of hypoxia inducible factor-1α (HIF-1α) by inhibiting heat shock protein 90 (HSP90). This
Sonodynamic antitumor effect of protoporphyrin IX disodium salt on S180 solid tumor
Liu Q, et al.
Chemotherapy, 53(6), 429-436 (2007)
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