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263443

1-Bromo-2,4-difluorobenzene

98%

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About This Item

Linear Formula:
BrC6H3F2
CAS Number:
348-57-2
Molecular Weight:
192.99
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24855973
EC Number:
206-479-4
Beilstein/REAXYS Number:
1680892
MDL number:
MFCD00000330
Assay:
98%
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assay

98%

refractive index

n20/D 1.505 (lit.)

bp

145-146 °C (lit.)

mp

−4 °C (lit.)

density

1.708 g/mL at 25 °C (lit.)

functional group

bromo, fluoro

SMILES string

Fc1ccc(Br)c(F)c1

InChI

1S/C6H3BrF2/c7-5-2-1-4(8)3-6(5)9/h1-3H

InChI key

MGHBDQZXPCTTIH-UHFFFAOYSA-N

General description

1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid.

Application

1-Bromo-2,4-difluorobenzene has been used in:
  • preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
  • enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

125.6 °F - closed cup

flash_point_c

52 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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