264423
2,5-Difluorobenzyl bromide
98%
Synonym(s):
α-Bromo-2,5-difluorotoluene
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About This Item
Linear Formula:
F2C6H3CH2Br
CAS Number:
Molecular Weight:
207.02
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
285-651-0
MDL number:
Product Name
2,5-Difluorobenzyl bromide, 98%
InChI key
ONWGSWNHQZYCFK-UHFFFAOYSA-N
InChI
1S/C7H5BrF2/c8-4-5-3-6(9)1-2-7(5)10/h1-3H,4H2
SMILES string
Fc1ccc(F)c(CBr)c1
assay
98%
refractive index
n20/D 1.526 (lit.)
density
1.609 g/mL at 25 °C (lit.)
functional group
bromo
fluoro
Application
2,5-Difluorobenzyl bromide has been used in the synthesis of:
- novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors, for the potential treatment of Alzheimer′s disease
- sulfonamide, amide and acyclic amine derivatives
signalword
Danger
hcodes
Hazard Classifications
Flam. Liq. 2 - Skin Corr. 1B
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
60.8 °F - closed cup
flash_point_c
16 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
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Ping Chen et al.
Bioorganic & medicinal chemistry letters, 21(6), 1880-1886 (2011-02-16)
A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases, while derivative 20k displayed long half life and modest oral bioavailability in
Martin Teall et al.
Bioorganic & medicinal chemistry letters, 15(10), 2685-2688 (2005-05-03)
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
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