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273937

6,7-Dimethoxy-1-tetralone

Name: 6,7-Dimethoxy-1-tetralone
Brand: ALDRICH

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₄O₃

CAS Number:

13575-75-2

Molecular Weight:

206.24

NACRES:

NA.22

PubChem Substance ID:

24856554

UNSPSC Code:

12352100

MDL number:

MFCD00134100

Assay:

97%

Form:

powder

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Properties

Quality Level

100

assay

97%

form

powder

mp

98-100 °C (lit.)

functional group

ketone

SMILES string

COc1cc2CCCC(=O)c2cc1OC

InChI

1S/C12H14O3/c1-14-11-6-8-4-3-5-10(13)9(8)7-12(11)15-2/h6-7H,3-5H2,1-2H3

InChI key

YNNJHKOXXBIJKK-UHFFFAOYSA-N

Description

General description

6,7-Dimethoxy-1-tetralone reacts with 2-amino-4,5-dimethoxyacetophenone to form 5,6-dihydro-2,3,9,10-tetramethoxybenz[c]acridine.

Application

6,7-Dimethoxy-1-tetralone was used in the synthesis of 2-bromotetralones by undergoing bromination. It was also used as a precursor to quinolines with dopaminergic activity, naphthols with anti-inflammatory activity and benzophenanthridine alkaloids with antitumor activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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The Journal of Organic Chemistry, 57, 5907-5907 (1992)

2-Aminotetralones: novel inhibitors of MurA and MurZ.

Colin J Dunsmore et al.

Bioorganic & medicinal chemistry letters, 18(5), 1730-1734 (2008-02-12)

Several 2-aminotetralones were identified as novel inhibitors of the bacterial enzymes MurA and MurZ. A number of these inhibitors demonstrated antibacterial activity against Staphylococcus aureus and Escherichia coli with MICs in the range 8-128 microg/ml. Based on structure-activity relationships we

Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines.

J C Craig et al.

Journal of medicinal chemistry, 32(5), 961-968 (1989-05-01)

A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the

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Global Trade Item Number

SKU	GTIN
273937-1G	04061825584140
273937-5G	04061826151815