Skip to Content
Merck
CN

278823

4-Chloro-1-butanol

technical grade, ~85%

Synonym(s):

Tetramethylene chlorohydrin

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
HO(CH2)4Cl
CAS Number:
928-51-8
Molecular Weight:
108.57
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24856834
MDL number:
MFCD00002967
Beilstein/REAXYS Number:
1731408

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

4-Chloro-1-butanol, technical grade, ~85%

InChI

1S/C4H9ClO/c5-3-1-2-4-6/h6H,1-4H2

SMILES string

OCCCCCl

InChI key

HXHGULXINZUGJX-UHFFFAOYSA-N

grade

technical grade

assay

~85%

form

liquid

refractive index

n20/D 1.453 (lit.)

bp

84-85 °C/16 mmHg (lit.)

density

1.088 g/mL at 25 °C (lit.)

functional group

chloro
hydroxyl

storage temp.

2-8°C

Quality Level

200

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

General description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.

Other Notes

Contains tetrahydrofuran and HCl

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

96.8 °F - closed cup

flash_point_c

36 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCK0710
BCBP6420V
BCCC9499
BCBG4312V
BCBG4312

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Koki Harigaya et al.
Chemical & pharmaceutical bulletin, 62(4), 395-398 (2014-04-04)
The analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) is a challenging task. The target detection limit (DL) in an API is typically around 1 ppm (1 µg/g API). Therefore, a sensitive and selective analytical method is required for their
Damion K Corrigan et al.
The Journal of pharmacy and pharmacology, 61(4), 533-537 (2009-03-21)
Alkylating agents are potentially genotoxic impurities that may be present in drug products. These impurities occur in pharmaceuticals as by-products from the synthetic steps involved in drug production, as impurities in starting materials or from in-situ reactions that take place

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service