280550
4-Diphenylmethoxy-1-methylpiperidine hydrochloride
95%
Synonym(s):
4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C19H23NO · HCl
CAS Number:
Molecular Weight:
317.85
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
205-049-3
MDL number:
Assay:
95%
InChI key
LPRLDRXGWKXRMQ-UHFFFAOYSA-N
InChI
1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
SMILES string
Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3
assay
95%
mp
203-205 °C (lit.)
functional group
ether, phenyl
Quality Level
Gene Information
human ... HRH1(3269)
Related Categories
General description
4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.
Application
4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.
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T Ohno et al.
Journal of the neurological sciences, 182(2), 95-97 (2001-01-04)
A long-term follow-up study was made of three patients with cerebrotendinous xanthomatosis (CTX) associated with parkinsonism, two of whom were siblings. Besides typical CTX symptoms, all three patients showed severe parkinsonism. This observation has been rarely reported in CTX. The
M A Lung et al.
Rhinology, 25(2), 95-100 (1987-06-01)
The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses
N Shibata et al.
Rinsho shinkeigaku = Clinical neurology, 30(9), 978-984 (1990-09-01)
Two sibling cases of cerebrotendinous xanthomatosis with parkinsonism were reported. One was a woman of 39 years old, and another was her sister of 36 years old. In both cases, febrile convulsion appeared on 1.5 year old, and mental deterioration
Gennady B Lapa et al.
European journal of pharmacology, 506(3), 237-240 (2005-01-04)
Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse
M Vasudevan et al.
Journal of pharmaceutical and biomedical analysis, 24(1), 25-31 (2000-12-07)
A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH
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