280550
4-Diphenylmethoxy-1-methylpiperidine hydrochloride
95%
Synonym(s):
4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C19H23NO · HCl
CAS Number:
Molecular Weight:
317.85
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
205-049-3
MDL number:
Assay:
95%
Quality Level
assay
95%
mp
203-205 °C (lit.)
functional group
ether, phenyl
SMILES string
Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3
InChI
1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
InChI key
LPRLDRXGWKXRMQ-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
General description
4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.
Application
4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.
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N Shibata et al.
Rinsho shinkeigaku = Clinical neurology, 30(9), 978-984 (1990-09-01)
Two sibling cases of cerebrotendinous xanthomatosis with parkinsonism were reported. One was a woman of 39 years old, and another was her sister of 36 years old. In both cases, febrile convulsion appeared on 1.5 year old, and mental deterioration
T Ohno et al.
Journal of the neurological sciences, 182(2), 95-97 (2001-01-04)
A long-term follow-up study was made of three patients with cerebrotendinous xanthomatosis (CTX) associated with parkinsonism, two of whom were siblings. Besides typical CTX symptoms, all three patients showed severe parkinsonism. This observation has been rarely reported in CTX. The
Robert Weis et al.
European journal of medicinal chemistry, 43(4), 872-879 (2007-08-24)
2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy. Their activity against Mycobacterium tuberculosis H(37)Rv as well as their
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 280550-10G | 04061833045626 |