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Merck
CN

281255

1,4-Dihydroxy-2-naphthoic acid

97%

Synonym(s):

1,4-Dihydroxy-2-carboxy naphthoic acid, 1,4-Dihydroxy-2-naphthalenecarboxylic acid, 1,4-Dihydroxy-2-naphthoate

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About This Item

Linear Formula:
(HO)2C10H5CO2H
CAS Number:
31519-22-9
Molecular Weight:
204.18
NACRES:
NA.22
PubChem Substance ID:
24856853
UNSPSC Code:
12352100
EC Number:
250-674-7
MDL number:
MFCD00010370
Assay:
97%

Key Documents

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Product Name

1,4-Dihydroxy-2-naphthoic acid, 97%

InChI key

VOJUXHHACRXLTD-UHFFFAOYSA-N

InChI

1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

SMILES string

OC(=O)c1cc(O)c2ccccc2c1O

assay

97%

mp

220 °C (dec.) (lit.)

functional group

carboxylic acid

Quality Level

100

Related Categories

General description

1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii is known to promote the proliferation of Bifidobacterium. It has potential therapeutic application for psoriasis treatment.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBF3225V
STBC4215V
STBC2929V
MKBD8659
STBB4596

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Biosynthesis of vitamin K (menaquinone) in bacteria.
R Bentley et al.
Microbiological reviews, 46(3), 241-280 (1982-09-01)
Pallavi P Murugkar et al.
Journal of oral microbiology, 12(1), 1814666-1814666 (2020-11-20)
The vast majority of bacteria on earth have not yet been cultivated. There are many bacterial phyla with no cultivated examples including most members of the Candidate Phylum Radiation with the exception of human oral isolates from the phylum Saccharibacteria.
Site of prenylation reaction in synthesis of phylloquinone (vitamin K1) by spinach chloroplasts.
G Schultz et al.
European journal of biochemistry, 117(2), 329-332 (1981-07-01)
Y Saito et al.
Journal of biochemistry, 89(5), 1445-1452 (1981-05-01)
1,4-Dihydroxy-2-naphthoate:polyprenyltransferase was detected in the membrane fraction from Micrococcus luteus. The specificity of the enzyme ws so tolerant as regards the prenyl-donating substrate that prenyl pyrophosphates ranging in chain length from C15 to C45 were active as substrates. The monophosphate
Masayuki Uchida et al.
Regulatory toxicology and pharmacology : RTP, 60(2), 262-267 (2010-12-22)
Propionibacterium freudenreichii ET-3 (7025) culture, a cell-free product of whey fermentation by P. freudenreichii ET-3, has been shown to promote the growth of Bifidobacteria through the action of 1,4-dihydroxy-2-naphthoic acid (DHNA). Here we report the results of two clinical studies
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