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284572

4-Aminobenzamide

Name: 4-Aminobenzamide
Brand: ALDRICH

98%

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About This Item

Linear Formula:

H₂NC₆H₄CONH₂

CAS Number:

2835-68-9

Molecular Weight:

136.15

NACRES:

NA.22

PubChem Substance ID:

24857167

UNSPSC Code:

12352100

EC Number:

220-612-3

MDL number:

MFCD00007999

Assay:

98%

Form:

solid

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Properties

Quality Level

100

assay

98%

form

solid

mp

181-183 °C (lit.)

functional group

amide

SMILES string

NC(=O)c1ccc(N)cc1

InChI

1S/C7H8N2O/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H2,9,10)

InChI key

QIKYZXDTTPVVAC-UHFFFAOYSA-N

Description

Application

4-Aminobenzamide was used as a poly(ADP-ribose)polymerase (PADPRP) inhhibitor to study the death of target cells by cytotoxic effector cells using the nuclear enzyme poly(ADP-ribose)polymerase (PADPRP).

pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Effect of inhibitors of poly(ADP-ribose)polymerase on the radiation response of HeLa S3 cells.

P Burgman et al.

Radiation research, 119(2), 380-386 (1989-08-01)

The purpose of this study was to investigate possible involvement of poly(ADP-ribosyl)ation reactions in X-ray-induced cell killing, repair of potentially lethal damage (PLD), and formation and repair of radiation-induced DNA damage. As tools we used the inhibitors of poly(ADP-ribose)polymerase, 3-aminobenzamide

Interferon-gamma inhibits insulin release and induces cell death in the pancreatic beta-cell line INS-1 independently of nitric oxide production.

R Laffranchi et al.

Experimental cell research, 237(1), 217-222 (1998-01-07)

Interferon-gamma is among the cytokines which have been implicated as effector molecules of beta-cell destruction in autoimmune diabetes. Its mechanism of action is, however, largely unknown. In the present study rat pancreatic beta-cells, INS-1, were incubated with rat interferon-gamma (rIRN-gamma)

Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.

E Ben-Hur et al.

Radiation research, 97(3), 546-555 (1984-03-01)

Postirradiation incubation of V79 Chinese hamster cells with inhibitors of poly(ADP-ribose) synthesis was found to potentiate the killing of cells by X rays. Potentiation increased with incubation time and with concentration of the inhibitor. Preirradiation incubation had only a small

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Global Trade Item Number

SKU	GTIN
284572-25G	04061826253564
284572-100G	04061838348456