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286044

Harmine

98%

Synonym(s):

7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

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About This Item

Empirical Formula (Hill Notation):
C13H12N2O
CAS Number:
442-51-3
Molecular Weight:
212.25
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24857229
EC Number:
207-131-4
Beilstein/REAXYS Number:
178813
MDL number:
MFCD00004958
Assay:
98%
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description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.

Quality Level

100

assay

98%

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

mp

262-264 °C (lit.)

SMILES string

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

InChI

1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

InChI key

BXNJHAXVSOCGBA-UHFFFAOYSA-N

Gene Information

human ... CDC2(983), CYP2D6(1565)

General description

The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.

Application

Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs).

Biochem/physiol Actions

Central nervous system stimulant.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP4312
BCCM8043
BCCK2340
BCCH1202
BCCC5443

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Katie L Uhl et al.
Cancer cell international, 18, 82-82 (2018-07-07)
Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities
Raphaël Frédérick et al.
Journal of medicinal chemistry, 55(14), 6489-6501 (2012-07-10)
To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor. Of the synthesized compounds, the
Mohammad Amjadi et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 689-694 (2013-11-30)
This article reports on a novel fluorescence resonance energy transfer (FRET) system between harmine and silver nanoparticles (AgNPs), in which harmine acts as the donor and AgNPs act as the acceptor. As a result of FRET, harmine fluorescence is quenched
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Global Trade Item Number

SKUGTIN
286044-1G04061826259689