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Merck
CN

301485

1-Chloroethyl chloroformate

98%

Synonym(s):

ACE-Cl

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About This Item

Linear Formula:
CH3CHClOCOCl
CAS Number:
50893-53-3
Molecular Weight:
142.97
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24858191
EC Number:
256-834-2
Beilstein/REAXYS Number:
1747601
MDL number:
MFCD00000647
Assay:
98%
Form:
liquid

Key Documents

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InChI key

QOPVNWQGBQYBBP-UHFFFAOYSA-N

InChI

1S/C3H4Cl2O2/c1-2(4)7-3(5)6/h2H,1H3

SMILES string

CC(Cl)OC(Cl)=O

vapor pressure

3.25 psi ( 20 °C)

assay

98%

form

liquid

Quality Level

100, 200

bp

118-119 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

functional group

chloro

storage temp.

2-8°C

Related Categories

General description

1-Chloroethyl chloroformate is used as a selective dealkylating agent for tertiary amines.

Application

1-Chloroethyl chloroformate was used:
  • for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection
  • as catalyst in chemoselective desilylation of silyl-protected alcohols
  • as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications
  • as reagent to cleave benzhydryl groups from amines

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

104.9 °F - closed cup

flash_point_c

40.5 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
10728BJV
10728BJ
BCBF6561V
53596PJ
1449006V

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Preparation of< i> N</i>-demethylated drug metabolites for analytical purposes using 1-chloroethyl chloroformate.
Pelander A, et al.
Forensic Science International, 85(3), 193-198 (1997)
Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol
Yeom CE, et al.
Tetrahedron, 61(52), 12227-12237 (2005)
Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol.
Yeom C-E, et al.
Tetrahedron, 61(52), 12227-12237 (2005)
Tetrahedron, 62, 6869-6869 (2006)
Ahmed Alnajjar et al.
Electrophoresis, 25(10-11), 1592-1600 (2004-06-10)
Methods for separation and determination of multiple drugs of abuse in biological fluids using capillary electrophoresis (CE) with native fluorescence and laser-induced fluorescence (LIF) detection are described herein. Using native fluorescence, normorphine, morphine, 6-acetyl morphine (6-AM), and codeine were analyzed

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