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Merck
CN

301507

2-Mercapto-1-methylimidazole

≥99%

Synonym(s):

Methimazole, 1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole

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About This Item

Empirical Formula (Hill Notation):
C4H6N2S
CAS Number:
60-56-0
Molecular Weight:
114.17
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
24858194
EC Number:
200-482-4
Beilstein/REAXYS Number:
108646
MDL number:
MFCD00179321
Assay:
≥99%

Key Documents

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InChI key

PMRYVIKBURPHAH-UHFFFAOYSA-N

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

SMILES string

CN1C=CNC1=S

assay

≥99%

mp

144-147 °C (lit.)

Gene Information

human ... CYP1A2(1544), TPO(7173)

Related Categories

General description

Sensitive detection of 2-mercapto-1-methylimidazole by Au-Ag-Au double shell nanoparticles-based localized surface plasmon resonance and surface-enhanced Raman scattering biosensor was reported.

Application

2-Mercapto-1-methylimidazole was employed as hydrophobic charge-induction chromatography ligand for antibody purification. It was also used in preparation of nitrile functionalized methimazole-based room temperature ionic liquids.

pictograms

Health hazardExclamation mark
GHS08,GHS07

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

target_organs

Endocrine system

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1A - Skin Sens. 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF8187V
WXBF8282V
WXBF2417V
WXBD9115V
WXBD5308V

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Xue Liao et al.
Talanta, 117, 203-208 (2013-11-12)
In this paper, Au-Ag-Au double shell nanoparticles were prepared based on the reduction of the metal salts HAuCl4 and AgNO3 at the surface of seed particles. Due to the synergistic effect between Au and Ag, the hybrid nanoparticles are particularly
Hui-Li Lu et al.
Journal of chromatography. A, 1278, 61-68 (2013-01-23)
Hydrophobic charge-induction chromatography (HCIC) is a novel technology for antibody purification. The ligand densities and pore properties of HCIC resins have significant effects on the separation behavior of protein, however, the understandings are quite limited. In the present work, new
Amal I Siriwardana et al.
The Journal of organic chemistry, 75(24), 8376-8382 (2010-11-18)
The alkylation reaction of 2-mercapto-1-methylimidazole 1b with 2-chloroacetonitrile and 2-chloropropionitrile produced S-alkyl methimazole chlorides 2a and 2b which were subjected to anion metathesis with lithium bis(trifluoromethanesulfonyl)amide, LiNTf(2), to afford nitrile functionalized methimazole-based room temperature ionic liquids 3a and 3b in
Coralie Leblicq et al.
Pediatrics, 131(2), e616-e619 (2013-01-09)
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrotropin receptor antibodies increased after administration of (131)I. Therefore, chorea in this patient
Nicole R van Veenendaal et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(2), 684-691 (2012-11-15)
Antithyroid medications are the preferred therapy for the treatment of Graves' disease during pregnancy. Propylthiouracil (PTU) is favored over methimazole (MMI) due to potential teratogenic concerns with MMI. This study was to determine the teratogenic potential of MMI and PTU
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