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308560

4-Amino-6-chloro-1,3-benzenedisulfonamide

Name: 4-Amino-6-chloro-1,3-benzenedisulfonamide
Brand: ALDRICH

98%

Synonym(s):

3-Chloroaniline-4,6-disulfonamide, 4-Amino-6-chlorobenzene-1,3-disulfonamide

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About This Item

Linear Formula:

H₂NC₆H₂(Cl)(SO₂NH₂)₂

CAS Number:

121-30-2

Molecular Weight:

285.73

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24858677

EC Number:

204-463-1

Beilstein/REAXYS Number:

1083877

MDL number:

MFCD00007933

Assay:

98%

Form:

powder

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Properties

Quality Level

100

assay

98%

form

powder

mp

257-261 °C (lit.)

functional group

chloro

SMILES string

Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O

InChI

1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)

InChI key

IHJCXVZDYSXXFT-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)

Description

General description

4-Amino-6-chloro-1,3-benzenedisulfonamide is a potent inhibitor of gastric pathogen, Helicobacter pylori (hpCA).

Application

4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Mass spectrometric behavior of thiazide-based diuretics after electrospray ionization and collision-induced dissociation.

Mario Thevis et al.

Analytical chemistry, 74(15), 3802-3808 (2002-08-15)

The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and common fragmentation patterns, the generations of which

Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.

T Okuda et al.

Chemical & pharmaceutical bulletin, 35(8), 3516-3518 (1987-08-01)

Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythrocytes.

M Yamazaki et al.

Chemical & pharmaceutical bulletin, 38(10), 2882-2883 (1990-10-01)

2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot

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Global Trade Item Number

SKU	GTIN
308560-100G	04061826674826
308560-5G	04061826674840