308560
4-氨基-6-氯-1,3-苯二磺酰胺
98%
别名:
5-氯-2,4-二磺酰胺基苯胺, 4-氨基-6-氯-1,3-苯二磺酰胺
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关于此项目
线性分子式:
H2NC6H2(Cl)(SO2NH2)2
化学文摘社编号:
分子量:
285.73
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-463-1
Beilstein/REAXYS Number:
1083877
MDL number:
产品名称
4-氨基-6-氯-1,3-苯二磺酰胺, 98%
InChI key
IHJCXVZDYSXXFT-UHFFFAOYSA-N
InChI
1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)
SMILES string
Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O
assay
98%
form
powder
mp
257-261 °C (lit.)
functional group
chloro
Quality Level
Gene Information
human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)
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Application
4-氨基-6-氯-1,3-苯二磺酰胺通过与适当标记的醛缩合，可用于合成氘代噻嗪类化合物。
General description
4-氨基-6-氯-1,3-苯二磺酰胺是胃病原体幽门螺杆菌（Helicobacter pylori ，hpCA）的有效抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Mario Thevis et al.
Analytical chemistry, 74(15), 3802-3808 (2002-08-15)
The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and common fragmentation patterns, the generations of which
M Yamazaki et al.
Chemical & pharmaceutical bulletin, 38(10), 2882-2883 (1990-10-01)
2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot
Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.
T Okuda et al.
Chemical & pharmaceutical bulletin, 35(8), 3516-3518 (1987-08-01)
B R Thomas et al.
Journal of chromatography. B, Biomedical applications, 657(2), 383-394 (1994-07-15)
A stability-indicating, quality control analysis method was developed and validated for the diuretic drug substances hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ). Micellar electrokinetic capillary chromatography employing the anionic detergent sodium dodecyl sulfate at 30 mM in 20 mM sodium borate buffer
K Deventer et al.
Journal of chromatography. A, 1216(12), 2466-2473 (2009-02-04)
In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide diuretics include compounds which are very unstable and hydrolyse in
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