Skip to Content
Merck
CN

317500

(1S,2R)-(+)-Norephedrine

98%

Synonym(s):

(1S,2R)-2-Amino-1-phenyl-1-propanol, erythro-α-(1-aminoethyl)benzyl alcohol, D-(+)-Norephedrine, Phenylpropanolamine

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
C6H5CH(OH)CH(CH3)NH2
CAS Number:
37577-28-9
Molecular Weight:
151.21
UNSPSC Code:
12352116
NACRES:
NA.22
PubChem Substance ID:
24859081
MDL number:
MFCD00064411
Beilstein/REAXYS Number:
2802896

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

(1S,2R)-(+)-Norephedrine, 98%

InChI

1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m1/s1

SMILES string

C[C@@H](N)[C@@H](O)c1ccccc1

InChI key

DLNKOYKMWOXYQA-VXNVDRBHSA-N

description

Drug Control: Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

assay

98%

form

solid

optical activity

[α]20/D +40°, c = 7 in 1 M HCl

drug control

Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

mp

51-54 °C (lit.)

functional group

amine
hydroxyl
phenyl

storage temp.

2-8°C

Quality Level

200

Related Categories

Application

(1S,2R)-(+)-Norephedrine may be used in the preparation of dendritic ligands, which on combining with Ru(II) complexes form efficient asymmetric transfer hydrogenation catalysts. It may also be used in the preparation of N-((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)furan-2-carboxamide. This chiral amide can efficiently catalyze the enantioselective ethylation of aromatic and heteroaromatic aldehydes to secondary alcohols in the absence of titanium tetraisopropoxide as promotor.

General description

(1S,2R)-(+)-Norephedrine is an enantiomer of ephedrine mainly used as a chiral auxiliary for asymmetric synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCX6621
MKCV9789
MKCV9788
MKCV9786
MKCW4783

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chiral amide from (1S, 2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes.
Ananthi N, et al.
Tetrahedron Asymmetry, 20(15), 1731-1735 (2009)
Dendritic catalysts for asymmetric transfer hydrogenation based (1S, 2R)-norephedrine derived ligands.
Liu PN, et al.
Tetrahedron Asymmetry, 14(16), 2481-2485 (2003)
Ana Caroline Costa Sa et al.
Scientific reports, 9(1), 8795-8795 (2019-06-21)
Growing evidence suggests that peripheral factors to the brain driving neuro-inflammation could affect Alzheimer's Disease (AD) and Parkinson's Disease (PD) severity. Herpes simplex virus type 1 (HSV1) infection has been associated with AD while other related viruses, including cytomegalovirus (CMV)
Archana Hinduja
Frontiers in neurology, 11, 71-71 (2020-03-03)
Background: Posterior reversible encephalopathy syndrome (PRES) is an acute neurotoxic syndrome that is characterized by a spectrum neurological and radiological feature from various risk factors. Common neurological symptoms includes headache, impairment in level of consciousness, seizures, visual disturbances, and focal
Stefan W Toennes et al.
Journal of pharmaceutical and biomedical analysis, 179, 113008-113008 (2019-12-02)
Each year, synthetic drugs are occurring in high numbers in the illicit drug market. But data on their pharmacology and toxicology are scarcely available. Therefore, a pilot study was performed to evaluate excretion of 4-fluoroamphetamine (4FA) in humans and identify
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service