327190
Isobutyl nitrite
95%
Synonym(s):
2-Methylpropyl nitrite
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About This Item
Linear Formula:
(CH3)2CHCH2ONO
CAS Number:
Molecular Weight:
103.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
208-819-7
MDL number:
Assay:
95%
Form:
liquid
InChI key
APNSGVMLAYLYCT-UHFFFAOYSA-N
InChI
1S/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3
SMILES string
CC(C)CON=O
assay
95%
form
liquid
refractive index
n20/D 1.373 (lit.)
bp
66-67 °C (lit.)
density
0.87 g/mL at 25 °C (lit.)
functional group
O-nitroso, nitroso
storage temp.
2-8°C
Quality Level
Related Categories
General description
Isobutyl nitrite was extensively used as room odorizers. It is a popular recreational drug.
Application
Isobutyl nitrite was used to study inhalant-induced immunotoxicity.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - Muta. 2
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
-5.8 °F - closed cup
flash_point_c
-21 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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Inhaled isobutyl nitrite produced lung inflammation with increased macrophage TNF-alpha and nitric oxide production.
L S Soderberg et al.
Advances in experimental medicine and biology, 402, 187-189 (1996-01-01)
W Kielbasa et al.
AAPS pharmSci, 2(2), E11-E11 (2001-12-14)
Our objective was to examine the pharmacokinetic/hemodynamic properties of inhaled isobutyl nitrite (ISBN) in rats. ISBN is one of the volatile organic nitrites that has been used primarily as a drug of abuse. Recent studies indicate, however, that these compounds
Review of the physiological effects of amyl, butyl, and isobutyl nitrites.
T J Haley
Clinical toxicology, 16(3), 317-329 (1980-05-01)
L S Soderberg et al.
Experimental hematology, 24(7), 848-853 (1996-06-01)
Isobutyl nitrite is representative of a group of inhalants abused primarily by male homosexuals; abuse of this drug may be a risk factor for AIDS or Kaposi's sarcoma. Using a 14-day exposure regimen, we previously reported that inhaled isobutyl nitrite
Lee S F Soderberg et al.
Toxicology letters, 132(1), 37-45 (2002-06-27)
Nitrite inhalant abuse has been correlated with HIV and Kaposi's sarcoma. Mouse models of inhalant exposure show immunosuppression and loss of immune cells. In the present study, isobutyl nitrite caused a dose-dependent loss of viability of a macrophage cell line.
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