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329274

2-Methoxy-5-nitrophenol

Name: 2-Methoxy-5-nitrophenol
Brand: ALDRICH

98%

Synonym(s):

5-Nitroguaiacol

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About This Item

Linear Formula:

CH₃OC₆H₃(NO₂)OH

CAS Number:

636-93-1

Molecular Weight:

169.13

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24859781

EC Number:

211-269-0

Beilstein/REAXYS Number:

2047074

MDL number:

MFCD00015561

Assay:

98%

Form:

powder

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Properties

assay

98%

form

powder

bp

110-112 °C/1 mmHg (lit.)

mp

103-107 °C (lit.)

SMILES string

COc1ccc(cc1O)[N+]([O-])=O

InChI

1S/C7H7NO4/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4,9H,1H3

InChI key

KXKCTSZYNCDFFG-UHFFFAOYSA-N

Description

General description

2-Methoxy-5-nitrophenol is the substitution photoproduct formed on irradiation of 2-chloro-4-nitroanisole at 25°C in aqueous NaOH.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Temperature-dependent regioselectivity of nucleophilic aromatic photosubstitution. Evidence that activation energy controls reactivity.

Gene G Wubbels et al.

The Journal of organic chemistry, 78(10), 4834-4839 (2013-05-02)

Irradiation (λ > 330 nm) of 2-chloro-4-nitroanisole (1) at 25 °C in aqueous NaOH forms three substitution photoproducts: 2-methoxy-5-nitrophenol (2), 2-chloro-4-nitrophenol (3), and 3-chloro-4-methoxyphenol (4), in chemical yields of 69.2%, 14.3%, and 16.5%. The activation energies for the elementary steps

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Nenad Manevski et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(1), 126-139 (2014-10-24)

Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fresh full-thickness human skin explants

Global Trade Item Number

SKU	GTIN
329274-25G	04061838348746