335665
7-Hydroxycoumarinyl-4-acetic acid
97%
Synonym(s):
Umbelliferone-4-acetic acid
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About This Item
Empirical Formula (Hill Notation):
C11H8O5
CAS Number:
Molecular Weight:
220.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
204777
Assay:
97%
Form:
powder
Quality Level
assay
97%
form
powder
mp
212 °C (dec.) (lit.)
functional group
carboxylic acid, ester
SMILES string
OC(=O)CC1=CC(=O)Oc2cc(O)ccc12
InChI
1S/C11H8O5/c12-7-1-2-8-6(3-10(13)14)4-11(15)16-9(8)5-7/h1-2,4-5,12H,3H2,(H,13,14)
InChI key
BNHPMQBVNXMPDU-UHFFFAOYSA-N
Application
7-Hydroxycoumarinyl-4-acetic acid was used in the synthesis of novel and specific enzyme substrates for Maroteaux-Lamy (MPS VI) and Morquio A (MPS IVA) diseases. It was also employed as ionic liquid matrice for MALDI-TOF MS of proteins, peptides and carbohydrates.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Trisha A Duffey et al.
Bioorganic & medicinal chemistry letters, 20(20), 5994-5996 (2010-09-14)
In continued efforts to develop enzymatic assays for lysosomal storage diseases appropriate for newborn screening laboratories we have synthesized novel and specific enzyme substrates for Maroteaux-Lamy (MPS VI) and Morquio A (MPS IVA) diseases. The sulfated monosaccharide derivatives were found
Erland J F Demant et al.
The Biochemical journal, 363(Pt 3), 809-815 (2002-04-20)
The kinetics of the interaction of long-chain fatty acids (referred to as fatty acids) with albumin is critical to understanding the role of albumin in fatty acid transport. In this study we have determined the kinetics of fatty acid dissociation
E J Demant
Analytical biochemistry, 267(2), 366-372 (1999-02-26)
A covalent complex between bovine serum albumin and 7-hydroxycoumarin-4-acetic acid (BSA-HCA) shows a strong fluorescence band at lambdamax = 450 nm upon excitation at 375 nm. Quenching of the fluorescence emission accompanies the association of fatty acids (FA) to BSA-HCA
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 335665-1G | 04061826662434 |
| 335665-5G | 04061833546796 |