Skip to Content
Merck
CN

337110

2-Fluoro-4-methylaniline

99%

Synonym(s):

2-Fluoro-p-toluidine

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
FC6H3(CH3)NH2
CAS Number:
452-80-2
Molecular Weight:
125.14
NACRES:
NA.22
PubChem Substance ID:
24860458
UNSPSC Code:
12352100
MDL number:
MFCD00040975
Assay:
99%
Form:
liquid

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

2-Fluoro-4-methylaniline, 99%

InChI

1S/C7H8FN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

SMILES string

Cc1ccc(N)c(F)c1

InChI key

ZQEXBVHABAJPHJ-UHFFFAOYSA-N

assay

99%

form

liquid

refractive index

n20/D 1.533 (lit.)

bp

70-71 °C/7 mmHg (lit.)

density

1.108 g/mL at 25 °C (lit.)

functional group

fluoro

Looking for similar products? Visit Product Comparison Guide

Application

2-Fluoro-4-methylaniline was used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It was also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.

General description

Rat liver microsomal metabolism of 2-fluoro-4-methylaniline was studied by HPLC.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

174.2 °F - closed cup

flash_point_c

79 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
34596EJ
05415EJ
10326TH
00530PH
05026PH

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

S Boeren et al.
Xenobiotica; the fate of foreign compounds in biological systems, 22(12), 1403-1423 (1992-12-01)
1. Rat liver microsomal metabolism of 2-fluoro-, 2-chloro- and 2-bromo-4-methylaniline was investigated using h.p.l.c. Metabolites identified include products from side-chain C-hydroxylation (benzyl alcohols and benzaldehydes) and N-hydroxylation (hydroxylamines and nitroso derivatives). Aromatic ring hydroxylation was not a major reaction pathway.
Sharon T Marino et al.
Molecules (Basel, Switzerland), 9(6), 405-426 (2007-11-17)
In the past decade there has been a significant growth in the sales of pharmaceutical drugs worldwide, but more importantly there has been a dramatic growth in the sales of single enantiomer drugs. The pharmaceutical industry has a rising demand
J M Bentley et al.
Bioorganic & medicinal chemistry letters, 14(9), 2367-2370 (2004-04-15)
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service