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Merck
CN

341436

Tetramethyl orthosilicate

≥99%

Synonym(s):

Tetramethoxysilane

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About This Item

Linear Formula:
Si(OCH3)4
CAS Number:
Molecular Weight:
152.22
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
211-656-4
Beilstein/REAXYS Number:
1699658
MDL number:
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Product Name

Tetramethyl orthosilicate, ≥99%

InChI key

LFQCEHFDDXELDD-UHFFFAOYSA-N

InChI

1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3

SMILES string

CO[Si](OC)(OC)OC

vapor density

5.25 (vs air)

vapor pressure

13 hPa ( 20 °C)

assay

≥99%

form

liquid

refractive index

n20/D 1.368 (lit.)

bp

121-122 °C (lit.)

mp

−4 °C (lit.)

density

1.023 g/mL at 25 °C (lit.)

Quality Level

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Application

Tetramethyl orthosilicate can be used:
  • As a precursor to synthesize organic-inorganic coating materials by sol-gel processing method.
  • As an efficient reagent for direct amidation of aliphatic and aromatic carboxylic acids with amines and anilines.
  • As a precursor to fabricate SiO2 nanocomposite films by chemical vapor deposition(CVD) method.
  • As a selective catalyst ofC3-methylation of indole.
Used in the sol-gel synthesis of chromium-doped silicates and in the formation of hexagonal mesoporous silica layers.

General description

Tetramethyl orthosilicate is a colorless organosilicon compound consisting of four methoxy groups bonded to a silicon atom. On hydrolysis, it produces silicon dioxide and methanol. It has been widely used in catalysis, synthesis of nanomaterials, ceramics, zeolites, and coating materials.

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Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Fabrication and characteristics of SiOx films by plasma chemical vapor deposition of tetramethylorthosilicate
Mu-Rong Yang, et al.
Surface and Coatings Technology, 123, 204-209 (2000)
Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids
D. Christopher Braddock, et al.
Organic Letters, 20, 950-953 (2018)
Tetramethyl orthosilicate as a sharp-selective catalyst of C3-methylation of indole by supercritical methanol
I.V.Kozhevnikov, et al.
Journal of Supercritical Fluids, 69, 82-90 (2012)
Preparation of sol-gel hybrid materials from gamma-methacryloxypropyltrimethoxysilane and tetramethyl orthosilicate: study of the hydrolysis and condensation reactions
Amir A, et al.
Colloid and Polymer Science, 289, 1875-1883 (2011)
Zian Lin et al.
Chemical communications (Cambridge, England), 47(34), 9675-9677 (2011-07-30)
An inorganic-organic hybrid affinity monolithic column was synthesized by a novel "one-pot" approach. The resulting hybrid affinity monoliths have potential applications in specific recognition and enrichment of glycoproteins.

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