359513
1-Acetylpiperazine
99%
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About This Item
Empirical Formula (Hill Notation):
C6H12N2O
CAS Number:
Molecular Weight:
128.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
237-659-0
Beilstein/REAXYS Number:
112220
MDL number:
Assay:
99%
InChI key
PKDPUENCROCRCH-UHFFFAOYSA-N
InChI
1S/C6H12N2O/c1-6(9)8-4-2-7-3-5-8/h7H,2-5H2,1H3
SMILES string
CC(=O)N1CCNCC1
assay
99%
mp
31-34 °C (lit.)
solubility
methanol: soluble 1 g/10 mL, clear, colorless to faintly greenish-yellow
Quality Level
General description
Infrared and Raman spectra of 1-acetylpiperazine have been recorded in the region of 4000-40cm-1.
Application
1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Nesrin Emir et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 127, 388-395 (2014-03-19)
Infrared and Raman spectra of 1-acetylpiperazine (1-ap) have been recorded in the region of 4000-40cm(-1). The conformational isomers, optimized geometric parameters, normal mode frequencies and corresponding vibrational assignments of 1-ap (C6H12N2O) have been examined by density functional theory (DFT), with
Zu-Ping Wu et al.
Archiv der Pharmazie, 345(3), 175-184 (2011-10-13)
A series of novel 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives were synthesized. The cholinesterase inhibition assays indicated that most synthesized compounds exhibited good activity for acetylcholinesterase (AChE) and high selectivity index of AChE over butyrylcholinesterase (BuChE). Compound 12b exhibited the most potent
Tarek Mohamed et al.
Bioorganic & medicinal chemistry letters, 21(19), 5881-5887 (2011-08-30)
A group of 2-substituted N-(naphth-1-ylmethyl)pyrimidin-4-amines (6a-k) and N-benzhydrylpyrimidin-4-amines (7a-k) in conjunction with varying steric and electronic properties at the C-2 position were designed, synthesized and evaluated as dual cholinesterase and amyloid-β (Aβ)-aggregation inhibitors. The naphth-1-ylmethyl compound 6f (2-(4-cyclohexylpiperazin-1-yl)-N-(naphth-1-ylmethyl)pyrimidin-4-amine) exhibited optimum
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