363464
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride
97%
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About This Item
Empirical Formula (Hill Notation):
C13H18Cl2N2 · HCl
CAS Number:
Molecular Weight:
309.66
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
258-038-0
MDL number:
Assay:
97%
InChI key
JVLRNANYLVRULL-UHFFFAOYSA-N
InChI
1S/C13H18Cl2N2.ClH/c14-5-2-6-16-7-9-17(10-8-16)13-4-1-3-12(15)11-13;/h1,3-4,11H,2,5-10H2;1H
SMILES string
Cl[H].ClCCCN1CCN(CC1)c2cccc(Cl)c2
assay
97%
mp
198-203 °C (lit.)
functional group
chloro
Quality Level
Related Categories
General description
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is present as impurity in nefazodone hydrochloride (pharmaceutical formulation). Synthesis of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is reported.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis of 1-(3-Chlorophenyl)-4-(3-Chloropropyl)-Piperazine Hydrochloride.
<BIG>Mai-Chun S, et al. </BIG>
Fine Chemicals / ????, 35(5) (2005)
D Sreenivas Rao et al.
Journal of pharmaceutical and biomedical analysis, 26(4), 629-636 (2001-08-23)
A simple, selective and reproducible reversed-phase liquid chromatography (LC) method has been developed for the quantitative determination of nefazodone hydrochloride (I) in the presence of its related impurities, namely 5-ethyl-4-(2-phenoxyethyl)-2H-1,2,4-triazol-3-(4H)one (II), 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine hydrochloride (III) and 1,1(1)-trimethylene-bis[4-(3-chlorophenyl) piperazine] hydrochloride (IV).
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