373605
6,6′-Dithiodinicotinic acid
technical grade, 85%
Synonym(s):
Bis[3-Carboxypyridine] 6,6′-disulfide, Bis[3-carboxypyridine] 6,6′-disulfide
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About This Item
Empirical Formula (Hill Notation):
C12H8N2O4S2
CAS Number:
Molecular Weight:
308.33
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
239-729-6
MDL number:
Assay:
85%
Form:
solid
grade
technical grade
Quality Segment
assay
85%
form
solid
mp
263-265 °C (lit.)
functional group
carboxylic acid, disulfide
SMILES string
OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1
InChI
1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
InChI key
GSASOFRDSIKDSN-UHFFFAOYSA-N
General description
6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.
Application
6,6′-Dithiodinicotinic acid may be employed as:
- specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
- modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
- dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
- water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
- chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
- spectrophotometric determination of thiols and of total glutathione in human blood
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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