377406
3,4-Dimethoxy-3-cyclobutene-1,2-dione
99%
Synonym(s):
Dimethyl squarate
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About This Item
Linear Formula:
(CH3O)2C4(=O)2
CAS Number:
Molecular Weight:
142.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
99%
Form:
solid
InChI
1S/C6H6O4/c1-9-5-3(7)4(8)6(5)10-2/h1-2H3
SMILES string
COC1=C(OC)C(=O)C1=O
InChI key
SZBNZTGCAMLMJY-UHFFFAOYSA-N
assay
99%
form
solid
mp
55-57 °C (lit.)
functional group
ether, ketone
storage temp.
2-8°C
Quality Level
Related Categories
General description
3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) is a cyclobutene derivative. It reacts with hydroxylamine derivatives to afford 3-hydroxyamino-4-methoxy-3-cyclobutene-1,2-diones.
Application
3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) may be used in the synthesis of the following compounds:
- chiral squaramides, highly enantioselective catalyst for the Friedel-Crafts reactions of indoles
- 3-(hydroxyamino)-4-methoxy-3-cyclobutene-1,2-dione
- squarate derivatives of the O-SP-core antigens
- methyl squarate derivative of the Ogawa O-SP-core antigen
- o-quinodimethanes
- benzocyclobutenes
- quinones
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Kerriann K Badal et al.
Cell reports, 26(3), 507-517 (2019-01-17)
Mechanisms that regulate the bi-directional transport of mitochondria in neurons for maintaining functional synaptic connections are poorly understood. Here, we show that in the pre-synaptic sensory neurons of the Aplysia gill withdrawal reflex, the formation of functional synapses leads to
Hydroxylamin-Derivate der Quadratsaure.
Zinner G, et al.
Arch. Pharm. (Weinheim), 318(11), 977-983 (1985)
Peng Xu et al.
Bioconjugate chemistry, 22(10), 2179-2185 (2011-09-09)
Bacterial O-SP-core antigens can be conjugated to proteins in the same, simple way as synthetic, linker-equipped carbohydrates by applying squaric acid chemistry. Introduction of spacers (linkers) to either O-SP-core antigens or protein carriers, which is involved in commonly applied protocols
Mohammad Murshid Alam et al.
PLoS neglected tropical diseases, 8(2), e2683-e2683 (2014-02-12)
Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children. Here we report the evaluation in mice of a
The Journal of Organic Chemistry, 59, 3284-3284 (1994)
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