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390585

Suberohydroxamic acid

Name: Suberohydroxamic acid
Brand: ALDRICH

95%

Synonym(s):

N,N′-Dihydroxyoctanediamide, SBHA, Suberoyl bis-hydroxamic acid

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About This Item

Linear Formula:

[-(CH₂)₃CONHOH]₂

CAS Number:

38937-66-5

Molecular Weight:

204.22

NACRES:

NA.22

PubChem Substance ID:

24864150

UNSPSC Code:

12352100

MDL number:

MFCD00192455

Assay:

95%

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Properties

Quality Level

100

assay

95%

mp

153-155 °C (lit.)

functional group

amine

SMILES string

ONC(=O)CCCCCCC(=O)NO

InChI

1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)

InChI key

IDQPVOFTURLJPT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

HDAC inhibitor

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC₅₀ values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000490091

0000347343

0000358937

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Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.

Li Ning et al.

The oncologist, 13(2), 98-104 (2008-02-29)

Medullary thyroid carcinoma (MTC) is a neuroendocrine (NE) malignancy that frequently metastasizes and has limited treatments. We recently reported that ectopic expression of Notch-1 in human MTC cells suppresses growth. The objective of this study was to evaluate the ability

Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53.

Jiansen Li et al.

Oncology reports, 37(1), 458-464 (2016-12-23)

Anaplastic thyroid cancer (ATC), usually derived from well-differentiated thyroid cancers is one of the most lethal human endocrine malignancies. In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular

PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo.

Mohamed Rahmani et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 20(18), 4849-4860 (2014-07-30)

The aim of this study is to explore the efficacy and define mechanisms of action of coadministration of the PI3K/mTOR inhibitor BEZ235 and pan-HDAC inhibitor panobinostat in diffuse large B-cell lymphoma (DLBCL) cells. Various DLBCL cells were exposed to panobinostat

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Global Trade Item Number

SKU	GTIN
390585-1G	04061831972672